Early Signs of End-Organ Damage in Retinal Arterioles in Patients with Type 2 Diabetes Compared to Hypertensive Patients

Autor:	Iris Kistner, Stefanie Friedrich, Joanna Harazny, Christian Ott, Agnes Jumar, Roland E. Schmieder, Georg Michelson
Rok vydání:	2016
Předmět:	Adult Male medicine.medical_specialty Time Factors Retinal Artery Physiology End organ damage 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Retina 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo Physiology (medical) Internal medicine Laser-Doppler Flowmetry medicine Humans Molecular Biology Aged Creatinine Cholesterol business.industry Retinal Hypertrophy Middle Aged medicine.disease Peripheral Arterioles medicine.anatomical_structure Endocrinology Diabetes Mellitus Type 2 chemistry Case-Control Studies Hypertension Female Cardiology and Cardiovascular Medicine business
Zdroj:	Microcirculation. 23:447-455
ISSN:	1073-9688
DOI:	10.1111/micc.12291
Popis:	Background Eutrophic and hypertrophic remodeling are major vascular hallmarks for hypertension and diabetes-associated microvascular end-organ damage in peripheral arterioles. The aim of this study is to compare retinal arterioles of diabetic, hypertensive, and healthy individuals. Methods Retinal parameters were assessed in 99 patients with T2DM, 158 hypertensive, and 149 healthy individuals. WT and CA of retinal arterioles (80-140 μm) were measured noninvasively and in vivo by scanning laser Doppler flowmetry (Heidelberg Engineering, Germany). Results After adjustment for values differing between the groups (age, BMI, gender, HDL cholesterol and serum creatinine, systolic office BP), patients with T2DM showed no significant difference in WT (14.2 ± 3), and CA (4199 ± 1107) in comparison with hypertensive patients (WT = 13.3 ± 4, p = 0.18, CA = 3862 ± 1546, p = 0.10) and healthy individuals (WT = 13.1 ± 3, p = 0.55, CA = 3864 ± 1216, p = 0.86). However, the subgroup of patients with diabetes duration of more than 60 months showed greater WT (14.9 ± 4, p = 0.04) and CA (4557 ± 1137, p = 0.02) than the hypertensive group and greater WT (p = 0.04) and CA (p = 0.03) than the healthy group, which is consistent with hypertrophic remodeling. Conclusion In the early stage of T2DM no hypertrophic remodeling was seen in retinal arterioles. However, hypertrophic remodeling was found in diabetic patients with more than 60 months duration of disease.
Databáze:	OpenAIRE
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