Argon Atmospheric Plasma Treatment Promotes Burn Healing by Stimulating Inflammation and Controlling the Redox State
Autor: | Jennyffer Ione de Souza Silva, Leonardo Bagne, Marcelo Augusto Marretto Esquisatto, Maraiara Aparecida de Oliveira, Lucas Buzeli de Souza, Bruno Bellotti Lopes, Thiago Antônio Moretti de Andrade, Amanda Tavares Pereira, Maria Esméria Corezola do Amaral, Gláucia Maria Tech dos Santos, Andrea Aparecida de Aro |
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Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Plasma Gases Angiogenesis Immunology Context (language use) Inflammation Pharmacology Antioxidants Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Animals Immunology and Allergy Second-Degree Burn Medicine Argon Rats Wistar Wound Healing business.industry Interleukin Fibroblasts Rats Oxidative Stress Atmospheric Pressure 030104 developmental biology 030220 oncology & carcinogenesis Tumor necrosis factor alpha medicine.symptom Burns Wound healing business Oxidation-Reduction |
Zdroj: | Inflammation. 43:2357-2371 |
ISSN: | 1573-2576 0360-3997 |
Popis: | Burns are a public health problem, with second-degree burns as one of the most common types. Although intense inflammation worsens burn healing, effective therapies are scarce. Thus, infections and hypertrophic scars may occur, which compromise patient quality of life and may delay healing. Argon atmospheric plasma (AP) has been shown to positively influence wound healing. In the context of identifying effective and alternative therapies for the treatment of second-degree burns, the present study evaluated AP in the treatment of second-degree burns in rats compared to that for sham treatment on the 2nd, 7th, 14th, and 21st days post-injury. Our results revealed proinflammatory effect for AP by recruiting predominantly neutrophils on the 7th day and macrophages on the 21st day compared to sham treatment, allowing a greater production of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-17, and also controlled the inflammation by IL-10 and transforming growth factor (TGF)-β1. AP also showed antioxidant activity important for controlling oxidative damage on the 2nd day. This favored the induction of angiogenesis from the 2nd day and induction fibroplasia and fibrillogenesis after the 14th day, which enhanced burn healing with the formation of a thinner burn eschar before the 21st day post-burn. Thus, AP effectively modulated the inflammatory phase of second-degree burn healing through the control of oxidative damage that favored the following phases. Therefore, AP is a relevant alternative in the treatment of second-degree burns. |
Databáze: | OpenAIRE |
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