Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug
| Autor: | Steven W. Hetts, Hee Jeung Oh, Nitash P. Balsara, Nikos Petzetakis, J. Yang, X. Chelsea Chen, Jay F. Yu, Anand S. Patel |
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| Rok vydání: | 2016 |
| Předmět: |
Letter
Materials science Polymers and Plastics 02 engineering and technology 010402 general chemistry 01 natural sciences Macromolecular and Materials Chemistry Inorganic Chemistry chemistry.chemical_compound Block (telecommunications) Scanning transmission electron microscopy Polymer chemistry Materials Chemistry medicine Copolymer Doxorubicin Cancer chemistry.chemical_classification Organic Chemistry Polymer Polyethylene 021001 nanoscience & nanotechnology 0104 chemical sciences Membrane chemistry 5.1 Pharmaceuticals Polystyrene 0210 nano-technology Biomedical engineering medicine.drug Physical Chemistry (incl. Structural) |
| Zdroj: | ACS macro letters, vol 5, iss 8 Chen, XC; Oh, HJ; Yu, JF; Yang, JK; Petzetakis, N; Patel, AS; et al.(2016). Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug. ACS Macro Letters, 5(8), 936-941. doi: 10.1021/acsmacrolett.6b00459. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/3nc0h87b ACS Macro Letters |
| DOI: | 10.1021/acsmacrolett.6b00459. |
| Popis: | © 2016 American Chemical Society. We introduce the use of block copolymer membranes for an emerging application, "drug capture". The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment. |
| Databáze: | OpenAIRE |
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