Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal
| Autor: | Jakub Włodarczyk, Jakub Fichna, Natalia Fabisiak, Adam Fabisiak, Martin Storr |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Review Gastroenterology Pathogenesis 03 medical and health sciences chemistry.chemical_compound Histamine receptor 0302 clinical medicine Internal medicine Receptors medicine Receptor Clinical treatment Irritable bowel syndrome business.industry medicine.disease histamine Ebastine Critical appraisal 030104 developmental biology chemistry Immunology Mast cells Etiology 030211 gastroenterology & hepatology Neurology (clinical) business Histamine |
| Zdroj: | Journal of Neurogastroenterology and Motility |
| ISSN: | 2093-0887 2093-0879 |
| Popis: | Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed. |
| Databáze: | OpenAIRE |
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