The protective effects ofSalvia officinalisessential oil compared to simvastatin against hyperlipidemia, liver, and kidney injuries in mice submitted to a high‐fat diet
| Autor: | Mariem Chaâbane, Abdelfattah El Feki, Mouna Turki, Fatma Koubaa-Ghorbel, Fatma Makni-Ayadi |
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| Rok vydání: | 2020 |
| Předmět: |
Simvastatin
medicine.medical_specialty Antioxidant medicine.medical_treatment Biophysics Aspartate transaminase Hyperlipidemias Diet High-Fat Kidney Mice chemistry.chemical_compound food Internal medicine Lactate dehydrogenase Hyperlipidemia Oils Volatile medicine Animals Salvia officinalis Pharmacology biology business.industry nutritional and metabolic diseases Lipid metabolism Cell Biology medicine.disease food.food Endocrinology Liver Alanine transaminase chemistry biology.protein lipids (amino acids peptides and proteins) business Food Science medicine.drug |
| Zdroj: | Journal of Food Biochemistry. 44 |
| ISSN: | 1745-4514 0145-8884 |
| Popis: | The present study was undertaken to evaluate the effects of Salvia officinalis essential oil (SEO) and simvastatin in hyperlipidemic mice. Animals were randomly divided into four groups. The control group received a standard diet. The high-fat diet (HFD) group received HFD. The third and fourth groups received HFD associated either with simvastatin (2.5 mg/kg bw) or with SEO (4 mg/kg bw). All animals were sacrificed after 8 weeks of treatment. SEO and simvastatin reduced in HFD mice body weight gain, hyperlipidemia, disruption of liver and renal functions and reactive oxygen species production. In fact, total cholesterol, triglycerides, total lipids, and low-density lipoprotein cholesterol levels, as well as aspartate transaminase, alanine transaminase, gamma-glutamyltranspeptidase and lactate dehydrogenase activities were reduced, while fecal lipids increased compared to those of HFD mice. The lipid-lowering effect of SEO was more effective than that of simvastatin. PRACTICAL APPLICATIONS: High-fat diet provokes hyperlipidemia, atherosclerosis, and abnormal lipid metabolism leading to the development of hepatic and renal dysfunctions as well as perturbations of the antioxidant status in liver and kidney. The results of this research highlight the beneficial effects of SEO in the management of these disorders without inducing side effects; in fact, the plant essential oil decreased lipids and improved the antioxidant status more than did a synthetic drug. |
| Databáze: | OpenAIRE |
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