Post hoc assessment of the relationship among coronary stenosis, electrocardiography, and ventricular function in patients with heart disease
| Autor: | Kimberly Padawer, Christopher Bitetzakis, Igor Sunjic, Jared Tur, Srinivas M. Tipparaju, Aarti Patel, Nidhi Patel, Wesley Hamlin, Siva K. Kumar, Edin Sadic |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Risk medicine.medical_specialty Post hoc Heart disease Physiology Coronary Artery Disease Coronary artery disease Electrocardiography chemistry.chemical_compound Text mining Physiology (medical) Internal medicine Natriuretic Peptide Brain Humans Ventricular Function Medicine In patient cardiovascular diseases Aged Retrospective Studies Pharmacology Creatinine medicine.diagnostic_test Ventricular function business.industry Age Factors Coronary Stenosis Stroke Volume General Medicine Middle Aged medicine.disease chemistry Echocardiography cardiovascular system Cardiology Female business Biomarkers Glomerular Filtration Rate |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 99:1234-1239 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/cjpp-2020-0728 |
| Popis: | Cardiovascular diseases including cardiac arrhythmias lead to fatal events in patients with coronary artery disease; however, clinical associations from echocardiography, electrocardiography (ECG), and biomarkers remain unknown. We sought to identify the factors that may be related to elevated QRS intervals in patients with risk for coronary artery disease. In this study, we performed analysis of clinical data from 503 patients divided into two groups, i.e., patients with either 50% coronary artery stenosis. We further examined patients with elevated ECG parameters such as QRS > 100 ms and QTc > 440 ms. Patients with >50% coronary artery stenosis exhibited significant increases in age, triglycerides, and troponin levels. Further, ECG parameters demonstrated increased QRS and QTc durations, while echocardiographic parameters highlighted a decrease in ejection fraction (EF) and fractional shortening (FS). Patients with QTc > 440 ms exhibited increased brain natriuretic peptide and creatinine levels with a decrease in estimated glomerular filtration rate clearance rates. Patients with QRS > 100 ms had greater left ventricular (LV) mass and LV internal diameter in systole and diastole. Multimodal logistic regression showed significant relation between QTc, age, and creatinine. These findings suggest that patients with significant coronary stenosis may have lower EF and FS with prolonged QRS intervals, demonstrating greater risk for arrhythmic events. |
| Databáze: | OpenAIRE |
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