Microbes involving in carcinogenesis; growing state of the art
| Autor: | Mir Naser Seyyed Mousavi, Mehdi Yousefi, Bahareh Mehramuz, Farid Hajibonabi, Khalil Aziziyan, Hossein Samadi Kafil, Somayeh Shiralizadeh, Naser Alizadeh, Mohammad Yousef Memar |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Gene Transfer Horizontal Carcinogenesis Mutagenesis (molecular biology technique) Biology medicine.disease_cause Microbiology Communicable Diseases Insertional mutagenesis 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Animals Humans Gene Cell Proliferation Genetics Bacteria Cell growth Cancer medicine.disease 030104 developmental biology Infectious Diseases 030220 oncology & carcinogenesis Horizontal gene transfer Cancer cell Viruses |
| Zdroj: | Microbial pathogenesis. 125 |
| ISSN: | 1096-1208 |
| Popis: | Lateral gene transfer (LGT) has been demonstrated as a transfer process of novel genes between different species. LGT proceedings are occurring between microbes and plants, as well as between microbes and animals. New evidence demonstrates that bacterial insertional mutagenesis may occur in cancer cells. Due to the important role of genetic changes in the increase of cell proliferation and cancer development, we reviewed the effects of microbial-animal LGT in human oncogenesis. In addition, viral DNA can induce cancer development by random insertion into cancer-related genes or by inducing translocations. In conclusion, growing evidence shows the contribution of the microbial genome in cancer and autoimmune disease. |
| Databáze: | OpenAIRE |
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