Dynamic contrast-enhanced ultrasonography (D-CEUS) for the early prediction of bevacizumab efficacy in patients with metastatic colorectal cancer
| Autor: | Giampaolo Gavelli, Andrea Casadei Gardini, Domenico Barone, Angela Ragazzini, Fabio Ferroni, Gianfranco Bandi, Giovanni Luca Frassineti, Devil Oboldi, Michele Amadori, Alice Rossi, Elena Amadori, Alessandro Passardi, Emanuela Scarpi |
|---|---|
| Přispěvatelé: | Amadori, Michele, Barone, Domenico, Scarpi, Emanuela, Oboldi, Devil, Amadori, Elena, Bandi, Gianfranco, Rossi, Alice, Ferroni, Fabio, Ragazzini, Angela, Casadei Gardini, Andrea, Frassineti, Giovanni Luca, Gavelli, Giampaolo, Passardi, Alessandro |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Colorectal cancer medicine.medical_treatment Contrast Media Early prediction 030218 nuclear medicine & medical imaging Metastasis Antineoplastic Agents Immunological 0302 clinical medicine Vascularity Nuclear Medicine and Imaging Prospective Studies Ultrasonography Aged 80 and over Metastatic colorectal cancer Liver Neoplasms Ultrasound Area under the curve General Medicine Middle Aged Bevacizumab Treatment Outcome Liver Area Under Curve 030220 oncology & carcinogenesis Female Radiology medicine.symptom Colorectal Neoplasms Perfusion medicine.drug Adult medicine.medical_specialty Urology Dynamic contrast-enhanced ultrasonography Tumour angiogenesis Radiology Nuclear Medicine and Imaging Disease-Free Survival 03 medical and health sciences Predictive Value of Tests medicine Humans Radiology Nuclear Medicine and imaging Aged Chemotherapy business.industry Image Enhancement medicine.disease business |
| Popis: | To investigate early changes in tumour perfusion parameters by dynamic contrast-enhanced ultrasonography (D-CEUS) and to identify any correlation with survival and tumour response in patients with metastatic colorectal cancer (CRC) treated with bevacizumab (B). Thirty-seven patients randomized to either chemotherapy (C) plus B or C alone were considered for this study. D-CEUS was performed at baseline and after the first treatment cycle (day 15). Four D-CEUS perfusion parameters were considered: derived peak intensity (DPI), area under the curve (AUC), slope of wash-in (A) and time to peak intensity (TPI). In patients treated with C plus B, a ≥22.5 % reduction in DPI, ≥20 % increase in TPI and ≥10 % reduction in AUC were correlated with higher progression-free survival in the C+B arm (p = 0.048, 0.024 and 0.010, respectively) but not in the C arm. None of the evaluated parameter modifications had a correlation with tumour response or overall survival. D-CEUS could be useful for detecting and quantifying dynamic changes in tumour vascularity as early as 15 days after the start of B-based therapy. Although these changes may be predictive of progression-free survival, no correlation with response or overall survival was found. • D-CEUS showed early changes in liver metastasis perfusion in colorectal cancer. • A decrease in tumour perfusion was associated with longer progression-free survival. • The decrease in perfusion was not correlated with higher overall survival. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|