Oxidant-antioxidant status in oral precancer and oral cancer patients
| Autor: | R. Kumaraguruparan, Siddavaram Nagini, Annamalai Thangavelu, R. Subapriya |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Toxicology medicine.disease_cause Gastroenterology Lipid peroxidation Superoxide dismutase chemistry.chemical_compound Internal medicine medicine chemistry.chemical_classification biology business.industry Glutathione peroxidase Cancer Glutathione medicine.disease stomatognathic diseases chemistry Catalase biology.protein business Oxidative stress |
| Zdroj: | Toxicology mechanisms and methods. 13(1) |
| ISSN: | 1537-6524 |
| Popis: | The present investigation was undertaken to examine the blood levels of lipid peroxides and the antioxidants superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase, and glutathione-S-transferase in oral precancer, preoperative, postoperative, and recurrent oral cancer patients with age- and sex-matched normal healthy subjects as controls. In patients with oral precancer and oral cancer, enhanced lipid peroxidation was accompanied by antioxidant depletion. These changes were more pronounced in patients with recurrent oral tumors. Twelve weeks after surgery, decreased lipid peroxidation was accompanied by increased antioxidant levels. The results of this study indicate that imbalance in the redox status of oral cancer patients may be due to enhanced lipid peroxidation and compromised antioxidant defenses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|