Influence of naringin on cadmium-induced genomic damage in human lymphocytes in vitro

Autor: Rahmi Bilaloglu, Ece Tüzün, Nilüfer Aydemir, Dilek Yilmaz, Ozgur Vatan
Přispěvatelé: Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü., Yılmaz, Dilek, Aydemir, Nilüfer Cinkılıç, Vatan, Özgür, Tüzün, Ece, Bilaloğlu, Rahmi, O-7508-2015, AAH-5296-2021
Rok vydání: 2011
Předmět:
Male
Battery industry
Health
Toxicology and Mutagenesis
Mutagenicity tests
Toxicology
medicine.disease_cause
Antioxidants
Citrus x paradisi
Induction
Lipid peroxidation
chemistry.chemical_compound
Free radical
Mitosis index
Mechanisms
Lymphocytes
Analysis of variance
Inhibition
Sister chromatid exchange
Modulation
Cadmium
Chemistry
Occupational exposure
Dna damage
Normal human
Cell protection
Aurantiin
Biochemistry
Flavanones
Metallurgy
Dose-response relationship
drug
Female
Lymphocyte
Mitotic index
Antioxidant
Chromosome aberration
Citrus paradisi
Human
Cells
cultured
Adult
inorganic chemicals
Cells
chemistry.chemical_element
Concentration response
Chloride
Drug interactions
Article
In vitro
Dna-repair
medicine
Humans
Sister chromatids
Chromosome aberrations
Naringin
Free-radical theory of aging
Flavonoids
Public Health
Environmental and Occupational Health
In vitro study
Environmental exposure
Aberrations
Young adult
Human cell
Oxidative stress
Cadmium Chlorides
Nephrotoxicity
Testes
Genotoxicity
Controlled study
Public
environmental & occupational health
Mutagens
Zdroj: Toxicology and Industrial Health. 28:114-121
ISSN: 1477-0393
0748-2337
Popis: Cadmium is an important toxic environmental heavy metal. Generally, occupational and environmental exposures to cadmium result from heavy metal mining, metallurgy and industrial use and the manufacturing of nickel–cadmium batteries, pigments and plastic stabilizers. Cadmium induces oxidative stress and alters the antioxidant system, resulting in oxidative DNA damage and lipid peroxidation. The effect of naringin, a grapefruit flavonone, on cadmium-induced genomic damage was studied by using an in vitro system to test for chromosomal aberrations and sister chromatid exchanges. Cadmium significantly increased the total chromosomal aberrations in human lymphocytes at concentrations of 20 and 40 μM, and although naringin alone did not induce any chromosomal aberrations, it decreased those induced by cadmium. The mitotic index was not affected by either cadmium or naringin. Cadmium also induced a significant number of sister chromatid exchanges, but naringin alone did not induce sister chromatid exchanges and was unable to decrease the frequency of sister chromatid exchanges induced by cadmium. Replicative index analysis revealed that naringin and cadmium did not significantly alter replicative index frequencies. In this study, we show that plant-based flavonoids, such as naringin, may reduce the genomic damage induced by cadmium and may protect the cellular environments from free radical damage by its possible antioxidative potential.
Databáze: OpenAIRE
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