Evaluation of C-reactive protein, Haptoglobin and cardiac troponin 1 levels in brachycephalic dogs with upper airway obstructive syndrome
| Autor: | Cyrill Poncet, Marta Planellas, Juan Lorente, Coralie Bertolani, Maria-Dolores Tabar, José J. Cerón, Josep M Closa, Rafaela Cuenca, Josep Pastor |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Upper airway Apnea Acute phase proteins Dogs Internal medicine Troponin I Animals Medicine Dog Diseases Respiratory system Hypoxia lcsh:Veterinary medicine Haptoglobins General Veterinary biology business.industry C-reactive protein Haptoglobin Acute-phase protein General Medicine medicine.disease veterinary(all) Obstructive sleep apnea C-Reactive Protein Gene Expression Regulation biology.protein Cardiology lcsh:SF600-1100 Female Stenotic nares Nasal Obstruction medicine.symptom Brachycephalic business Biomarkers Research Article Myocardial damage |
| Zdroj: | BMC Veterinary Research, Vol 8, Iss 1, p 152 (2012) BMC Veterinary Research Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona |
| ISSN: | 1746-6148 |
| DOI: | 10.1186/1746-6148-8-152 |
| Popis: | Background Brachycephalic dogs have unique upper respiratory anatomy with abnormal breathing patterns similar to those in humans with obstructive sleep apnea syndrome (OSAS). The objective of this study was to evaluate the correlation between anatomical components, clinical signs and several biomarkers, used to determine systemic inflammation and myocardial damage (C-reactive protein, CRP; Haptoglobin, Hp; cardiac troponin I, cTnI), in dogs with brachycephalic upper airway obstructive syndrome (BAOS). Results Fifty brachycephalic dogs were included in the study and the following information was studied: signalment, clinical signs, thoracic radiographs, blood work, ECG, components of BAOS, and CRP, Hp and cTnI levels. A high proportion of dogs with BAOS (88%) had gastrointestinal signs. The prevalence of anatomic components of BAOS was: elongated soft palate (100%), stenotic nares (96%), everted laryngeal saccules (32%) and tracheal hypoplasia (29.1%). Increased serum levels of biomarkers were found in a variable proportion of dogs: 14% (7/50) had values of CRP > 20 mg/L, 22.9% (11/48) had values of Hp > 3 g/L and 47.8% (22/46) had levels of cTnI > 0.05 ng/dl. Dogs with everted laryngeal saccules had more severe respiratory signs (p Conclusions According to the low percentage of patients with elevated levels of CRP and Hp, BAOS does not seem to cause an evident systemic inflammatory status. Some degree of myocardial damage may occur in dogs with BAOS that can be detected by cTnI concentration. |
| Databáze: | OpenAIRE |
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