Evaluation of low-density lipoprotein particle number distribution in patients with type 2 diabetes mellitus with low-density lipoprotein cholesterol50 mg/dl and non-high-density lipoprotein cholesterol80 mg/dl
| Autor: | Manuel Castro, Robert Honigberg, Jaime Burkle, Hector Malave, Thomas D. Dayspring, Ray Pourfarzib, Szilard Voros |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Databases Factual Low density lipoprotein cholesterol Coronary Artery Disease Risk Assessment Severity of Illness Index Cohort Studies chemistry.chemical_compound Age Distribution Internal medicine Medicine Distribution (pharmacology) Humans In patient Particle Size Sex Distribution Triglycerides Aged business.industry Cholesterol Incidence Non high density lipoprotein cholesterol Cholesterol HDL nutritional and metabolic diseases Type 2 Diabetes Mellitus Cholesterol LDL Middle Aged Prognosis Lipoproteins LDL Endocrinology chemistry Diabetes Mellitus Type 2 Cardiology lipids (amino acids peptides and proteins) Female Cardiology and Cardiovascular Medicine business Low-density lipoprotein particle Biomarkers Lipoprotein |
| Zdroj: | The American journal of cardiology. 110(5) |
| ISSN: | 1879-1913 |
| Popis: | Many patients with type 2 diabetes mellitus (T2DM) have relatively normal levels of low-density lipoprotein (LDL) cholesterol yet have increased risk for cardiovascular events. Distribution of lipoprotein subclasses in patients with T2DM who have achieved very low levels of LDL cholesterol (50 mg/dl) or non-high-density lipoprotein (HDL) cholesterol (80 mg/dl) have not been extensively examined. The aim of this study was to assess variations in lipoprotein particle concentration in patients with diabetes with "very low" LDL cholesterol and non-HDL cholesterol levels to elucidate the drivers of residual cardiovascular risk. Data were selected from a single large clinical laboratory database. Cases were patients with T2DM diagnosis codes (International Classification of Diseases, Ninth Revision, codes 250 to 250.93). Lipoprotein particle concentrations were analyzed using nuclear magnetic resonance spectroscopy. The Friedewald equation was used to calculate LDL cholesterol. Among the 1,970 patients with T2DM, the mean age was 61 years, and approximately 51% were men. At LDL cholesterol concentrations50 mg/dl (triglyceride150 mg/dl and HDL cholesterol40 mg/dl), 16% had LDL particle concentrations500 nmol/L, 70% had concentrations of 500 to 1,000 nmol/L, and 14% had concentrations1,001 nmol/L. At non-HDL cholesterol levels80 mg/dl, 8% had LDL particle concentrations500 nmol/L, 67% had concentrations of 500 to 1,000 nmol/L, and 25% had concentrations1,001 nmol/L. In conclusion, despite attainment of LDL cholesterol50 mg/dl or non-HDL cholesterol80 mg/dl, patients with diabetes exhibited significant variation in LDL particle levels, with most having LDL particle concentrations500 nmol/L, suggesting the persistence of potential residual coronary heart disease risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect