Respiratory tract lesions in guinea pigs exposed to sulfuric acid mist
| Autor: | William M. Busey, Finis L. Cavender, Beverly Y. Cockrell |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Pathology medicine.medical_specialty Endothelium Guinea Pigs Respiratory System Respiratory Tract Diseases Biology Toxicology law.invention Lesion law Edema medicine Animals Respiratory system Aerosols Inhalation Macrophages Sulfuric Acids Pollution Pulmonary Alveoli medicine.anatomical_structure Toxicity Female medicine.symptom Electron microscope Respiratory tract |
| Zdroj: | Journal of Toxicology and Environmental Health. 4:835-844 |
| ISSN: | 0098-4108 |
| Popis: | Guinea pigs were exposed in inhalation chambers to 25 mg/m 3 sulfuric acid mist 6 h/d for 2 d, and the acute respiratory effects were correlated by light and electron microscopy. This concentration of acid was selected since lower concentrations result in only slight effects while higher concentrations result in death. By light microscopy, the most prominent pulmonary lesion at 48 h was segmental alveolar hemorrhage and edema accompanied by proliferation of alveolar macrophages and type 2 pneumocytes. The segmental distribution of the pulmonary lesion was reaffirmed by scanning electron microscopy, while transmission electron microscopy showed injury to the distal airways and changes in the vascular endothelium. |
| Databáze: | OpenAIRE |
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