Giant cell arteritis: a multicenter observational study in Brazil
| Autor: | Karine Yoshiye Kajiyama Okamoto, Alexandre Wagner Silva de Souza, Samuel Katsuyuki Shinjo, Ana Beatriz Santos Bacchiega, Fabiano Ferreira Abrantes, Bruno Schau |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Vasculitis medicine.medical_specialty Biopsy Giant Cell Arteritis Methylprednisolone Statistics Nonparametric Polymyalgia rheumatica Sex Factors Risk Factors Prednisone Internal medicine medicine Humans Glucocorticoids Aged Retrospective Studies Aged 80 and over Aspirin lcsh:R5-920 business.industry Retrospective cohort study General Medicine Clinical Science Middle Aged medicine.disease Rheumatology Temporal Arteries Surgery Jaw claudication Multicenter Study Giant cell arteritis Methotrexate Antirheumatic Agents Female business lcsh:Medicine (General) Brazil medicine.drug |
| Zdroj: | Clinics; v. 68 n. 3 (2013); 317-322 Clinics; Vol. 68 Núm. 3 (2013); 317-322 Clinics; Vol. 68 No. 3 (2013); 317-322 Clinics Universidade de São Paulo (USP) instacron:USP Clinics, Vol 68, Iss 3, Pp 317-322 (2013) Clinics, Volume: 68, Issue: 3, Pages: 317-322, Published: 2013 |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVE: To describe demographic features, disease manifestations and therapy in patients with giant cell arteritis from referral centers in Brazil. METHODS: A retrospective cohort study was performed on 45 giant cell arteritis patients from three university hospitals in Brazil. Diagnoses were based on the American College of Rheumatology classification criteria for giant cell arteritis or temporal artery biopsy findings. RESULTS: Most patients were Caucasian, and females were slightly more predominant. The frequencies of disease manifestations were as follows: temporal headache in 82.2%, neuro-ophthalmologic manifestations in 68.9%, jaw claudication in 48.9%, systemic symptoms in 44.4%, polymyalgia rheumatica in 35.6% and extra-cranial vessel involvement in 17.8% of cases. Aortic aneurysms were observed in 6.6% of patients. A comparison between patients with biopsy-proven giant cell arteritis and those without temporal artery biopsies did not yield significant differences in disease manifestations. All patients were treated with oral prednisone, and intravenous methylprednisolone was administered to nearly half of the patients. Methotrexate was the most commonly used immunosuppressive agent, and low-dose aspirin was prescribed to the majority of patients. Relapses occurred in 28.9% of patients, and aspirin had a protective effect against relapses. Females had higher prevalences of polymyalgia rheumatica, systemic manifestations and jaw claudication, while permanent visual loss was more prevalent in men. CONCLUSIONS: Most of the clinical features of Brazilian giant cell arteritis patients were similar to those found in other studies, except for the high prevalence of neuro-ophthalmic manifestations and permanent blindness in the Brazilian patients. Aspirin had a protective effect on relapses. |
| Databáze: | OpenAIRE |
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