The oxidation catalytic converter reduces the inhibitory activity of soluble organic fractions of diesel particles on intercellular communication
| Autor: | Philippe Pornet, Isabelle Vanrullen, Catherine Chaumontet, Paule Martel, Frédéric Véran |
|---|---|
| Přispěvatelé: | Laboratoire de nutrition et sécurité alimentaire, Institut National de la Recherche Agronomique (INRA), ProdInra, Migration |
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
[SDV]Life Sciences [q-bio]
010501 environmental sciences medicine.disease_cause 01 natural sciences Cell junction 03 medical and health sciences Diesel fuel medicine Environmental Chemistry Carcinogen 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences Chemistry business.industry Gap junction General Chemistry CANCER [SDV] Life Sciences [q-bio] Cell culture Biophysics Particle RAT Telecommunications business Intracellular Genotoxicity |
| Zdroj: | Environmental Science and Technology Environmental Science and Technology, American Chemical Society, 2000, 34 (7), pp.1352-1358 |
| ISSN: | 0013-936X 1520-5851 |
| Popis: | The genotoxicity of diesel particles has been widely documented, and their tumor promoting effect has been reported recently using the gap junction intercellular communication (GJIC) assay. In the study, the ability of soluble organic fractions (SOF) of diesel particles emitted from cars equipped (WC) or not (WoutC) with the oxidation catalytic converter (OCC) and of particle SOF from an outdoor high polluted place (OHPP) to inhibit GJIC has been evaluated with two cell lines: a rat liver epithelial cell line (REL cells) and a rat pulmonary alveolar type II cell line (3T cells). With both cell lines, the results demonstrate that GJIC is strongly inhibited by WoutC, whereas it is much less reduced by WC ones: for REL cells, the activity of WC particles is 1/4 off the one of WoutC. Also, the authors show that the inhibition induced by WoutC is associated with a change in the GJ protein localization. Their results clearly show the effectiveness of the OCC technology in reducing both the tumor promoting activity and the genotoxicity of diesel particle SOF. (A) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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