HTLV-1/2 Infection in Blood Donors from a Non-Endemic Area (Catalonia, Spain) between 2008 and 2017: A 10-Year Experience
| Autor: | Piron, Maria, Salvador, Fernando, Caballero Requero, Estrella, Sánchez-Montalvá, Adrián, Bes, Marta, Casamitjana, Natàlia, Puig Sanz, Lluís, Molina Romero, Israel, Sauleda, Silvia, Universitat Autònoma de Barcelona |
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| Přispěvatelé: | Institut Català de la Salut, [Piron M, Bes M, Sauleda S] Banc de Sang i Teixits de Catalunya (Blood and Tissue Bank of Catalonia, BST), Transfusion Safety Laboratory, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREhd), Instituto de Salud Carlos III, Madrid, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Salvador F, Sánchez-Montalvá A, Molina I] Centre de Salut Internacional i Malalties Transmissibles Drassanes-Vall d'Hebron Hospital Universitari, Barcelona, Spain. Servei de Malalties Infecciones, Vall d’Hebron Hospital Universitari, Barcelona, Spain. PROSICS Barcelona, Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain. [Caballero E] Laboratori de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Casamitjana N] Banc de Sang i Teixits de Catalunya (Blood and Tissue Bank of Catalonia, BST), Transfusion Safety Laboratory, Barcelona, Spain. [Puig L] Banc de Sang i Teixits de Catalunya (Blood and Tissue Bank of Catalonia, BST), Transfusion Safety Laboratory, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREhd), Instituto de Salud Carlos III, Madrid, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male personas::donantes de tejidos::donantes de sangre [DENOMINACIONES DE GRUPOS] Blood Donors Virus Diseases::RNA Virus Infections::Retroviridae Infections::Deltaretrovirus Infections [DISEASES] Deltaretrovirus Virology Humans Malalties transmissibles Infeccions per retrovirus transfusion Other subheadings::Other subheadings::/transmission [Other subheadings] Human T-lymphotropic virus 1 screening virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Deltaretrovirus [ENFERMEDADES] Human T-lymphotropic virus 2 HTLV-I Infections HTLV-1/2 blood donors leukoreduction Spain Infectious Diseases Persons::Tissue Donors::Blood Donors [NAMED GROUPS] HTLV-1 HTLV-II Infections Otros calificadores::Otros calificadores::/transmisión [Otros calificadores] Female Donants de sang |
| Zdroj: | Scientia Viruses-Basel r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Viruses; Volume 14; Issue 9; Pages: 1975 Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona |
| ISSN: | 1999-4915 |
| Popis: | Spain; Screening; Transfusion España; Cribado; Transfusión Espanya; Cribratge; Transfusió Human T-cell lymphotropic virus type 1 and 2 (HTLV-1/2) screening is not mandatory in Spanish blood banks. In Catalonia, selective screening was introduced in 2008, followed by universal screening in 2011. We present herein a 10-year experience of HTLV testing in blood donors. HTLV-1/2 selective screening was performed using Ortho-Clinical Diagnostics HTLV-I/HTLV-II Ab-Capture ELISA between February 2008 and May 2009, then Abbott Prism HTLV-I/ HTLV-II assay until December 2010. Abbott Architect rHTLV-I/II assay was then used for HTLV-1/2 universal screening in pooled samples. INNO-LIA HTLV I/II Score (Fujirebio) and in-house HTLV-1/2 proviral DNA real-time PCR were used in reactive samples. Follow-up was offered to confirm HTLV-1/2 donors in Vall d’Hebron Hospital. Between 2008 and 2017, 51 blood donors were confirmed HTLV positive (46 HTLV-1, 4 HTLV-2 and 1 HTLV) out of 2,114,891 blood donations (1 in 41,468). Sixty-nine percent were female, median age was 40 years and most were born in Latin America (69%), followed by Europe (25%), Africa (4%) and Asia (2%). Screening of relatives and partners identified 12 additional HTLV-1 cases. Lookback studies did not show any HTLV-1/2 transmission. HTLV infections found in blood donors mirror epidemiological changes in the population of Spain. Consequently, HTLV should be considered a potential risk for recipients and calls for the design of optimal strategies to ensure transfusion safety. A.S.-M was supported by a postdoctoral grant “Juan Rodés” (JE18/00022) from the Instituto de Salud Carlos III through the Spanish Ministry of Economy and Competitiveness. |
| Databáze: | OpenAIRE |
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