Effect of expiratory positive airway pressure on sleep disordered breathing
| Autor: | Raphael Heinzer, Louise Dover, Yu L Lo, David P. White, Atul Malhotra, Amy S. Jordan, KE Stevenson |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Functional Residual Capacity Short Note Polysomnography Non-rapid eye movement sleep Body Mass Index Positive-Pressure Respiration Physiology (medical) medicine Tidal Volume Humans Tidal volume Expiratory Time Sleep Apnea Obstructive medicine.diagnostic_test business.industry Airway Resistance Apnea Middle Aged medicine.disease Obstructive sleep apnea Expiratory Reserve Volume Oxygen Anesthesia Female Neurology (clinical) medicine.symptom business Hypopnea Respiratory minute volume |
| Zdroj: | Sleep. 31(3) |
| ISSN: | 0161-8105 |
| Popis: | STUDY OBJECTIVES We sought to determine the effect of expiratory positive airway pressure on end expiratory lung volume (EELV) and sleep disordered breathing in obstructive sleep apnea patients. DESIGN Observational physiology study PARTICIPANTS We studied 10 OSA patients during sleep wearing a facial mask. We recorded 1 hour of NREM sleep without treatment (baseline) and 1 hour with 10 cm H2O EPAP in random order, while measuring EELV and breathing pattern. RESULTS The mean EELV change between baseline and EPAP was only 13.3 mL (range 2-25 mL). Expiratory time was significantly increased with EPAP compared to baseline 2.64 +/- 0.54 vs 2.16 +/- 0.64 sec (P = 0.002). Total respiratory time was longer with EPAP than at baseline 4.44 +/- 1.47 sec vs 3.73 +/- 0.88 sec (P = 0.3), and minute ventilation was lower with EPAP vs baseline 7.9 +/- 4.17 L/min vs 9.05 +/- 2.85 L/min (P = 0.3). For baseline (no treatment) and EPAP respectively, the mean apnea+hypopnea index (AHI) was 62.6 +/- 28.7 and 56.8 +/- 30.3 events per hour (P = 0.4). CONCLUSION In OSA patients during sleep, the application of 10 cm H2O EPAP led to prolongation of expiratory time with only marginal increases in FRC. These findings suggest important mechanisms exist to avoid hyperinflation during sleep. |
| Databáze: | OpenAIRE |
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