Extrahypothalamic effects of melatonin administration on serotonin and norepinephrine synthesis in female Syrian hamsters
| Autor: | J. P. Vriend, N. A. M. Alexiuk |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Serotonin
endocrine system medicine.medical_specialty medicine.drug_class Ovariectomy Hypothalamus Hamster Biology Melatonin Norepinephrine chemistry.chemical_compound Cricetinae Pons Internal medicine medicine Animals Neurotransmitter Biological Psychiatry Monoamine oxidase inhibitor Mesocricetus Hydroxyindoleacetic Acid Amygdala Pargyline Circadian Rhythm Psychiatry and Mental health Endocrinology Neurology chemistry Catecholamine Ovariectomized rat Female Neurology (clinical) hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of Neural Transmission. 94:43-53 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/bf01244982 |
| Popis: | The effects of daily late afternoon injections of melatonin for 10 weeks on the metabolism of serotonin (5-HT) and norepinephrine (NE) were examined in regional brain extracts of intact and ovariectomized (GX) Syrian hamsters. Accumulation of 5-HT and NE after administration of the monoamine oxidase inhibitor pargyline was used as a measure of the rate of neurotransmitter synthesis — with concentrations determined by HPLC with electrochemical detection. Daytime 5-HT synthesis was significantly decreased in the amygdala of melatonin-treated hamsters that had been GX (to 50% of GX controls). No significant effect on 5-HT synthesis could be detected in the mediobasal hypothalamus (MBH), however, a significant increase was demonstrated in the pontine brain stem of both intact and GX hamsters treated with melatonin. Daytime NE synthesis was decreased to levels not significantly different from zero in the amygdala of GX hamsters treated with melatonin, while in the brain stem, melatonin reduced NE synthesis in both intact and GX animals. The present data demonstrate that these melatonin effects on 5-HT and NE metabolism are not limited to the MBH and are not secondary to melatonin-induced changes in circulating levels of the ovarian steroids. |
| Databáze: | OpenAIRE |
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