D-Tagatose Feeding Reduces the Risk of Sugar-Induced Exacerbation of Myocardial I/R Injury When Compared to Its Isomer Fructose
| Autor: | Debora Collotta, Annunziatina Laurino, Emanuela Masini, Laura Lucarini, Silvia Sgambellone, Massimo Collino, Gustavo Provensi, Mariaconcetta Durante, Paola Failli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Ischemia Inflammation 030204 cardiovascular system & hematology medicine.disease_cause Biochemistry Genetics and Molecular Biology (miscellaneous) Biochemistry Proinflammatory cytokine fructose fructose myocardial ischemia inflammation oxidative stress D-tagatose 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Enos Internal medicine Medicine oxidative stress Molecular Biosciences Sugar D-tagatose lcsh:QH301-705.5 Molecular Biology Original Research biology business.industry inflammation myocardial ischemia Insulin Fructose biology.organism_classification medicine.disease 030104 developmental biology Endocrinology chemistry lcsh:Biology (General) medicine.symptom business Oxidative stress |
| Zdroj: | Frontiers in Molecular Biosciences Frontiers in Molecular Biosciences, Vol 8 (2021) |
| ISSN: | 2296-889X |
| DOI: | 10.3389/fmolb.2021.650962 |
| Popis: | It is known that fructose may contribute to myocardial vulnerability to ischemia/reperfusion (I/R) injury. D-tagatose is a fructose isomer with less caloric value and used as low-calorie sweetener. Here we compared the metabolic impact of fructose or D-tagatose enriched diets on potential exacerbation of myocardial I/R injury. Wistar rats were randomizedly allocated in the experimental groups and fed with one of the following diets: control (CTRL), 30% fructose-enriched (FRU 30%) or 30% D-tagatose-enriched (TAG 30%). After 24 weeks of dietary manipulation, rats underwent myocardial injury caused by 30 min ligature of the left anterior descending (LAD) coronary artery followed by 24 h′ reperfusion. Fructose consumption resulted in body weight increase (49%) as well as altered glucose, insulin and lipid profiles. These effects were associated with increased I/R-induced myocardial damage, oxidative stress (36.5%) and inflammation marker expression. TAG 30%-fed rats showed lower oxidative stress (21%) and inflammation in comparison with FRU-fed rats. Besides, TAG diet significantly reduced plasmatic inflammatory cytokines and GDF8 expression (50%), while increased myocardial endothelial nitric oxide synthase (eNOS) expression (59%). Overall, we demonstrated that D-tagatose represents an interesting sugar alternative when compared to its isomer fructose with reduced deleterious impact not only on the metabolic profile but also on the related heart susceptibility to I/R injury. |
| Databáze: | OpenAIRE |
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