Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2
| Autor: | Paulina Misztak, P. Pańczyszyn-Trzewik, Krzysztof Tokarski, Marcin Marciniak, Bartosz Bobula, Katarzyna Stachowicz, Magdalena Sowa-Kućma |
|---|---|
| Přispěvatelé: | Stachowicz, K, Sowa-Kucma, M, Panczyszyn-Trzewik, P, Misztak, P, Marciniak, M, Bobula, B, Tokarski, K |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
mGluR7 Pyridines Receptor Metabotropic Glutamate 5 Hippocampus Pharmacology Receptors Metabotropic Glutamate 03 medical and health sciences 0302 clinical medicine Animals Nitrobenzenes Mice Knockout Sulfonamides Behavior Animal Cyclooxygenase 2 Inhibitors Metabotropic glutamate receptor 5 Chemistry General Neuroscience Antagonist Protein level Modified Barnes maze TST COX-2 Thiazoles 030104 developmental biology MTEP Metabotropic glutamate receptor COX-2 inhibitor 030217 neurology & neurosurgery Co administration |
| Zdroj: | Neuroscience letters. 741 |
| ISSN: | 1872-7972 |
| Popis: | Our earlier study demonstrated, that antidepressant-like and also cognitive action of MTEP, a metabotropic glutamate receptor subtype 5 (mGluR5) antagonist, was influenced by cyclooxygenase-2 (COX-2) inhibition in mice. We detected a decrease in the mGluR7 protein level in the hippocampus (HC) of mice co-treated chronically with MTEP and NS398 (a COX-2 inhibitor). We found both antidepressant-like effects and cognitive to be associated with mGlu7 receptor-mediated mechanisms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect