Higher Fetal Insulin Resistance in Chinese Pregnant Women with Gestational Diabetes Mellitus and Correlation with Maternal Insulin Resistance
| Autor: | Qiu-wei Wang, Bin Zhang, Huiyan Wang, Bin Yu, Ming Zhang, Zi-qiang Zhu, Fang Cao, Rui-ping Huang, Hong Zhou, Xinhong Wang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Anatomy and Physiology endocrine system diseases medicine.medical_treatment Endocrinology Pregnancy Insulin-Secreting Cells Insulin Proinsulin Multidisciplinary Obstetrics and Gynecology Fasting Fetal Blood Gestational diabetes Cord blood Medicine Female hormones hormone substitutes and hormone antagonists Research Article Adult medicine.medical_specialty Science Endocrine System Fetus Insulin resistance Asian People Diabetes mellitus Internal medicine medicine Humans Gestational Diabetes Biology Diabetic Endocrinology Endocrine Physiology business.industry nutritional and metabolic diseases Prohormones medicine.disease Hormones Pregnancy Complications Diabetes Gestational Case-Control Studies Insulin Resistance business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 4, p e59845 (2013) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0059845 |
| Popis: | ObjectiveThe aim of this study was to determine the effect of gestational diabetes mellitus (GDM) on fetal insulin resistance or β-cell function in Chinese pregnant women with GDM.MeasurementsMaternal fasting blood and venous cord blood samples (reflecting fetal condition) were collected in 65 well-controlled Chinese GDM mothers (only given dietary intervention) and 83 control subjects. The insulin, glucose and proinsulin concentrations of both maternal and cord blood samples were measured, and the homeostasis model assessment of insulin resistance (HOMA-IR) and the proinsulin-to-insulin ratios (an indicator of fetal β-cell function) were calculated in maternal and cord blood respectively.ResultsBoth maternal and fetal levels of insulin, proinsulin and HOMA-IR but not proinsulin-to-insulin ratios were significantly higher in the GDM group than in the control group (maternal insulin, 24.8 vs. 15.4 µU/mL, P = 0.004, proinsulin, 23.3 vs. 16.2 pmol/L, P = 0.005, and HOMA-IR, 5.5 vs. 3.5, P = 0.041, respectively; fetal: insulin, 15.1 vs. 7.9 µU/mL, PConclusionsFetal insulin resistance was higher in Chinese pregnant women with GDM than control subjects, and correlated with maternal insulin resistance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|