Japanese Ethnicity Compared with Caucasian Ethnicity and Never-Smoking Status Are Independent Favorable Prognostic Factors for Overall Survival in Non-small Cell Lung Cancer: A Collaborative Epidemiologic Study of the National Hospital Organization Study Group for Lung Cancer (NHSGLC) in Japan and a Southern California Regional Cancer Registry Databases
| Autor: | Ryusei Saito, Yosihito Maruyama, Jason A. Zell, Akihide Matsumura, Atsuhisa Tamura, Argyrios Ziogas, Shimao Fukai, Sai-Hong Ignatius Ou, Masaaki Kawahara, Tomoya Kawaguchi |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Gerontology Oncology Lung Neoplasms Ethnic group 0302 clinical medicine Non-small cell lung cancer Japan Carcinoma Non-Small-Cell Lung Never-smoker 030212 general & internal medicine Young adult Child Aged 80 and over Prognostic factor education.field_of_study Smoking Cancer registry Middle Aged 3. Good health Survival Rate Treatment Outcome Child Preschool 030220 oncology & carcinogenesis Female Adult Pulmonary and Respiratory Medicine medicine.medical_specialty Adolescent Caucasian ethnicity Population Adenocarcinoma White People Young Adult 03 medical and health sciences Asian People Internal medicine medicine Carcinoma Humans Neoplasms Squamous Cell education Lung cancer Survival rate Japanese ethnicity Aged Neoplasm Staging Retrospective Studies business.industry Infant Newborn Infant Retrospective cohort study medicine.disease respiratory tract diseases Carcinoma Large Cell business |
| Zdroj: | Journal of Thoracic Oncology. 5(7):1001-1010 |
| ISSN: | 1556-0864 |
| DOI: | 10.1097/jto.0b013e3181e2f607 |
| Popis: | BackgroundWe previously reported that Asian ethnicity was a favorable prognostic factor for overall survival (OS) in non-small cell lung cancer (NSCLC). In this study, we performed a combined data analysis from a Japanese Cancer Registry and a regional California Cancer Registry to further validate this observation.MethodsRetrospective population-based analysis of Japanese and Caucasian patients with NSCLC with known smoking status from the Japanese National Hospital Organization Study Group for Lung Cancer and a Southern California Regional Cancer Registry between 1991 and 2001.ResultsA total of 15,185 Japanese and 13,332 US Caucasian patients were analyzed. Median age of Japanese patients was 68 years compared with 69 years for Caucasian patients (p < 0.0001). A total of 29.3% of Japanese compared with 7.3% Caucasian patients were never-smokers. Never-smoking status conferred significant improved OS for Japanese (p < 0.0001) and a trend for improved OS for Caucasian patients (p = 0.1282). Univariate analysis revealed Japanese patients with stage III (versus Caucasian; hazard ratio [HR] = 0.830, 95% confidence interval [CI]: 0.789-0.873, p < 0.0001) and IV disease (versus Caucasian; HR = 0.955, 95% CI: 0.915-0.997, p = 0.0369) had improved OS compared with Caucasian patients. Multivariate analysis revealed Japanese ethnicity (versus Caucasian; HR = 0.937, 95% CI: 0.898-0.978, p = 0.0028) and never-smoker status (versus ever-smoker; HR = 0.947, 95% CI: 0.909-0.987, p = 0.0104) to be independent favorable factors for OS in addition to younger age, female gender, early stage, and treatment received (surgery, radiation, and chemotherapy).ConclusionsJapanese ethnicity when compared with Caucasian ethnicity and never-smoker status are independent favorable prognostic factors for OS in NSCLC. |
| Databáze: | OpenAIRE |
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