Examination of the effect of agitation on the potency of the Ebola Zaire vaccine rVSVΔG-ZEBOV-GP
| Autor: | Harrison Davis, Lynne Ann Isopi, Jeffrey T. Blue, Tylina Dow |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Drug Storage
030231 tropical medicine Biology medicine.disease_cause Vibration 03 medical and health sciences 0302 clinical medicine Drug Stability Viral Envelope Proteins Chlorocebus aethiops medicine Potency Animals 030212 general & internal medicine Ebola Vaccines Vaccine Potency Ebolavirus General Veterinary General Immunology and Microbiology Public Health Environmental and Occupational Health Temperature Vaccine Stability Virology Infectious Diseases Molecular Medicine |
| Zdroj: | Vaccine. 38(12) |
| ISSN: | 1873-2518 |
| Popis: | The Ebolavirus vaccine (rVSVΔG-ZEBOV-GP) is stored at −80 to −60 °C and should be kept frozen for transport. Due to significant logistical challenges, frozen transport is not feasible for some remote locations. To determine if local distribution at 2–8 °C is a potential option for these locations, a study was conducted to evaluate the impact of agitation on the thawed vaccine. After up to 7 days of constant agitation, no impact on vaccine potency was evident for the agitated vaccine versus the corresponding vaccine kept stationary at 2–8 °C. In conclusion, in-country transport of the Ebolavirus vaccine, rVSVΔG-ZEBOV-GP, at 2–8 °C appears to be a feasible option for those remote locations where significant logistical challenges prohibit transporting the vaccine at −80 to −60 °C. |
| Databáze: | OpenAIRE |
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