Functional Interference Clusters in Cancer Patients With Bone Metastases: A Secondary Analysis of RTOG 9714
| Autor: | Deborah Watkins Bruner, Mack Roach, Sarah J. Ratcliffe, Ivy A. Petersen, Charles W. Scarantino, Andre Konski, Andrea M. Barsevick, William F. Hartsell, Jennifer L. James, Edward Chow, Robert Ivker, W. Demas, John H. Suh |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Randomization Varimax rotation Bone Neoplasms Walking Article law.invention Randomized controlled trial Quality of life Cronbach's alpha law Internal medicine Activities of Daily Living medicine Humans Interpersonal Relations Radiology Nuclear Medicine and imaging Karnofsky Performance Status Brief Pain Inventory Bone pain Aged Pain Measurement Aged 80 and over Principal Component Analysis Radiation business.industry Reproducibility of Results Radiotherapy Dosage Middle Aged Affect Mood Oncology Quality of Life Physical therapy Female medicine.symptom Sleep business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 76:1507-1511 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2009.04.024 |
| Popis: | Purpose To explore the relationships (clusters) among the functional interference items in the Brief Pain Inventory (BPI) in patients with bone metastases. Methods Patients enrolled in the Radiation Therapy Oncology Group (RTOG) 9714 bone metastases study were eligible. Patients were assessed at baseline and 4, 8, and 12 weeks after randomization for the palliative radiotherapy with the BPI, which consists of seven functional items: general activity, mood, walking ability, normal work, relations with others, sleep, and enjoyment of life. Principal component analysis with varimax rotation was used to determine the clusters between the functional items at baseline and the follow-up. Cronbach's alpha was used to determine the consistency and reliability of each cluster at baseline and follow-up. Results There were 448 male and 461 female patients, with a median age of 67 years. There were two functional interference clusters at baseline, which accounted for 71% of the total variance. The first cluster (physical interference) included normal work and walking ability, which accounted for 58% of the total variance. The second cluster (psychosocial interference) included relations with others and sleep, which accounted for 13% of the total variance. The Cronbach's alpha statistics were 0.83 and 0.80, respectively. The functional clusters changed at week 12 in responders but persisted through week 12 in nonresponders. Conclusion Palliative radiotherapy is effective in reducing bone pain. Functional interference component clusters exist in patients treated for bone metastases. These clusters changed over time in this study, possibly attributable to treatment. Further research is needed to examine these effects. |
| Databáze: | OpenAIRE |
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