Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma
| Autor: | Shea Ping Yip, Chuang Yuan, Michael Ying, Isabella Wai Yin Cheuk, Dora L.W. Kwong, Vincent W.C. Wu |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty Peroxisome proliferator-activated receptor gamma Pathology Genotype Nasopharyngeal neoplasm Single-nucleotide polymorphism Polymorphism Single Nucleotide Gastroenterology Risk Factors Carotid atherosclerosis Internal medicine Nasopharyngeal carcinoma medicine Humans Genetic Predisposition to Disease Radiology Nuclear Medicine and imaging cardiovascular diseases Aged Aged 80 and over Radiation Radiotherapy biology business.industry Research Haplotype Paraoxonase Nasopharyngeal Neoplasms Single nucleotide polymorphisms Middle Aged medicine.disease PON1 Oncology Radiology Nuclear Medicine and imaging cardiovascular system biology.protein Female Carotid plaque score business Biomarkers Follow-Up Studies |
| Zdroj: | Radiation Oncology (London, England) |
| ISSN: | 1748-717X |
| Popis: | Radiotherapy (RT) of the neck is commonly given to nasopharyngeal carcinoma (NPC) patients for preventing cervical lymph node metastasis. However, neck RT may induce the development of carotid atherosclerosis. The mechanisms of radiation-induced carotid atherosclerosis are still unclear and no previous study has investigated the genetic involvement of radiation-induced carotid atherosclerosis. The present study aims to determine the association between genetic polymorphisms and carotid atherosclerosis in patients treated with RT for nasopharyngeal carcinoma. The present study recruited 128 post-RT NPC patients. Carotid plaque score was assessed using ultrasonography. Thirteen single nucleotide polymorphisms (SNPs) that affect the function of anti-atherosclerotic genes, including SOD2, SOD3, CAT, PON1, PPARG, ADIPOQ, IL10, TGFB1 and NOS3, were genotyped. Association between the 13 SNPs and carotid atherosclerosis was evaluated using multiple regression after adjustment for covariates (PLINK). Multiple testing was corrected using Benjamini-Hochberg step-up false discovery rate controlling procedure. rs662 and rs705379 of PON1 were close to be significantly associated with carotid plaque score (Corrected P value, P cor = 0.0528 and P cor = 0.0842). When the two SNPs were combined together, TC haplotype in rs662-rs705379 of PON1 was significantly associated with higher carotid plaque score (P cor |
| Databáze: | OpenAIRE |
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