Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17
| Autor: | Tasuku Ogita, Suguru Shigemori, Takashi Sato, Ayane Mikami, Fu Namai, Takeshi Shimosato |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
green tea Endocrinology Diabetes and Metabolism lcsh:TX341-641 Inflammation Gut flora Pharmacology Inflammatory bowel disease 03 medical and health sciences 0302 clinical medicine inflammatory bowel disease Oral administration medicine Colitis Acute colitis Nutrition Original Research Nutrition and Dietetics biology business.industry Flavonifractor plautii Interleukin biology.organism_classification medicine.disease IL-17 lipoteichoic acid 030104 developmental biology 030220 oncology & carcinogenesis Lipoteichoic acid medicine.symptom business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Frontiers in Nutrition Frontiers in Nutrition, Vol 7 (2021) |
| ISSN: | 2296-861X |
| DOI: | 10.3389/fnut.2020.610946 |
| Popis: | Flavonifractor plautii (FP) has been reported to participate in the metabolism of catechins in the human gut. However, there is limited information on the immune regulatory effects of this bacterium. We confirmed that the administration of green tea increases the abundance of FP in the gut microbiota and investigated the effect of FP in a mouse colitis model. Mice were orally administered FP for 10 consecutive days; colonic inflammation was evaluated daily on the basis of stool consistency, gross rectal bleeding, and body weight. In the dextran sodium sulfate model, FP-exposed animals exhibited lower levels of inflammation and strong inhibition of interleukin (IL)-17 signaling. Moreover, lipoteichoic acid from FP was identified as the active component mediating IL-17 suppression. Thus, oral administration of FP appears to modulate gut inflammation and represents a viable and inexpensive oral microbial therapeutic. |
| Databáze: | OpenAIRE |
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