Semi-automated generation of individual computational models of the human head and torso from MR images
Autor: | Benjamin Kalloch, Arno Villringer, Mikhail Kozlov, André Pampel, Jens Bode, Mario Hlawitschka, Harald E. Möller, Bernhard Sehm, Pierre-Louis Bazin |
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Přispěvatelé: | Netherlands Institute for Neuroscience (NIN), Spinoza Centre for Neuroimaging, Brain and Cognition, Brein en Cognitie (Psychologie, FMG) |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Adult
Male Computer science ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION computer.software_genre 030218 nuclear medicine & medical imaging Pattern Recognition Automated 03 medical and health sciences Young Adult 0302 clinical medicine Electromagnetic Fields Voxel medicine Image Processing Computer-Assisted Journal Article Humans Radiology Nuclear Medicine and imaging Computer vision Segmentation Computer Simulation Gray Matter Cerebrospinal Fluid Skin Human head business.industry Phantoms Imaging Skull Brain Torso Image segmentation Pipeline (software) Magnetic Resonance Imaging White Matter Healthy Volunteers Simulation software medicine.anatomical_structure Spinal Cord Mesh generation Programming Languages Artificial intelligence business computer Head 030217 neurology & neurosurgery Algorithms Software |
Zdroj: | Magnetic Resonance in Medicine, 81, 2090-2105. John Wiley and Sons Inc. Magnetic Resonance in Medicine Magnetic Resonance in Medicine, 81(3), 2090-2105. John Wiley and Sons Inc. |
ISSN: | 0740-3194 |
Popis: | Purpose: Simulating the interaction of the human body with electromagnetic fields is an active field of research. Individualized models are increasingly being used, as anatomical differences affect the simulation results. We introduce a processing pipeline for creating individual surface-based models of the human head and torso for application in simulation software based on unstructured grids. The pipeline is designed for easy applicability and is publicly released on figshare. Methods: The pipeline covers image acquisition, segmentation, generation of segmentation masks, and surface mesh generation of the single, external boundary of each structure of interest. Two gradient-echo sequences are used for image acquisition. Structures of the head and body are segmented using several atlas-based approaches. They consist of bone/skull, subarachnoid cerebrospinal fluid, gray matter, white matter, spinal cord, lungs, the sinuses of the skull, and a combined class of all other structures including skin. After minor manual preparation, segmentation images are processed to segmentation masks, which are binarized images per segmented structure free of misclassified voxels and without an internal boundary. The proposed workflow is applied to 2 healthy subjects. Results: Individual differences of the subjects are well represented. The models are proven to be suitable for simulation of the RF electromagnetic field distribution. Conclusion: Image segmentation, creation of segmentation masks, and surface mesh generation are highly automated. Manual interventions remain for preparing the segmentation images prior to segmentation mask generation. The generated surfaces exhibit a single boundary per structure and are suitable inputs for simulation software. |
Databáze: | OpenAIRE |
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