Biocompatible Micelles Based on Comb-like PEG Derivates: Formation, Characterization, and Photo-responsiveness
| Autor: | Ye-Ting Shi, Congshan Zhu, Xiangsheng Liu, Shaopeng Pang, Jian Ji, Gongyan Liu, Chaojian Chen |
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| Rok vydání: | 2011 |
| Předmět: |
Polymers and Plastics
Polymers Ultraviolet Rays Biocompatible Materials Micelle Fluorescence spectroscopy Polyethylene Glycols chemistry.chemical_compound Drug Delivery Systems Polymer chemistry PEG ratio Materials Chemistry Humans MTT assay Micelles Drug Carriers Chemistry Organic Chemistry Hep G2 Cells Photochemical Processes Coumarin Controlled release Chemical engineering Self-assembly Hydrophobic and Hydrophilic Interactions Ethylene glycol Naphthoquinones |
| Zdroj: | Macromolecular Rapid Communications. 32:1077-1081 |
| ISSN: | 1022-1336 |
| DOI: | 10.1002/marc.201100196 |
| Popis: | A novel comb-like derivative CPEG-g-DNQ was prepared by incorporating light responsive 2-diazo-1,2-naphthoquinone (DNQ) groups into the structure of comb-like poly(ethylene glycol) (CPEG). DLS and TEM results showed that CPEG-g-DNQ self-assembled into spherical micelles with an average size of about 135 nm in water. Upon exposure to light, the micelles could be disrupted because of the conversion of hydrophobic DNQ to hydrophilic 3-indenecarboylic acid. Additionally, hydrophobic coumarin 102 was successfully loaded into the micelles and photo-induced ON-OFF release was demonstrated by fluorescence spectroscopy. MTT assay revealed that the micelles are biocompatible. These photo-responsive micelles might have great potential for controlled release of hydrophobic drugs. |
| Databáze: | OpenAIRE |
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