Thyroid-associated ophthalmopathy; quality of life follow-up of patients randomized to treatment with antithyroid drugs or radioiodine
| Autor: | Mirna Abraham-Nordling, Göran Wallin, Frank Träisk, Gertrud Berg, Jan Calissendorff, Bengt Hallengren, Pavo Hedner, Mikael Lantz, Ernst Nyström, Peter Åsman, Göran Lundell, Ove Törring |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Randomization Antithyroid drugs Endocrinology Diabetes and Metabolism medicine.medical_treatment Graves' disease Disease Iodine Radioisotopes Graves' ophthalmopathy Endocrinology Antithyroid Agents Quality of life Internal medicine Multicenter trial medicine Humans Aged Methimazole business.industry Antithyroid agent General Medicine Middle Aged medicine.disease Graves Disease Graves Ophthalmopathy Treatment Outcome Quality of Life Female business |
| Zdroj: | European Journal of Endocrinology. 163:651-657 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje-10-0475 |
| Popis: | ObjectiveThe objective of this study was to investigate quality of life (QoL) in patients with Graves' disease treated with radioiodine or antithyroid drugs.Design and methodsThe design of the study consists of an open, prospective, randomized multicenter trial between radioiodine and medical treatment. A total of 308 patients were included in the study group: 145 patients in the medical group and 163 patients in the radioiodine group. QoL was measured with a 36-item Short Form Health Status Survey questionnaire (SF-36) at six time points during the 48-month study period.ResultsPatient who developed or got worse of thyroid-associated ophthalmopathy (TAO) at any time point during the 4-year study period (TAO group) had lower QoL when no respect was paid to the mode of treatment.TAO occurred in 75 patients who had radioiodine treatment at some time point during the study period as compared with TAO in 40 medically treated patients (PComparisons between the group of patients who have had TAO versus the group without TAO, in relation to treatments and time, showed significantly decreased QoL scores for the TAO groups at several time points during the study.In patients without TAO, there were no differences in QoL related to mode of treatment.ConclusionsThe QoL in patients with Graves' ophthalmopathy was similar in radioiodine and medically treated patients, but patients who developed or had worsening of TAO had decreased QoL independent of mode of treatment. Furthermore, patients with TAO recovered physically within 1 year but it took twice as long for them to recover mentally. |
| Databáze: | OpenAIRE |
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