Peptide Regulation of Cells Renewal Processes in Kidney Tissue Cultures from Young and Old Animals
| Autor: | N. I. Chalisova, A. V. Dudkov, A P Ryzhak, Natalia Linkova, Ryzhak Ga, T. E. Nichik |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Aging Cell Apoptosis Peptide Biology Kidney Retina General Biochemistry Genetics and Molecular Biology Tissue culture Organ Culture Techniques medicine Animals Proliferation Marker Rats Wistar Cells Cultured Cell Proliferation chemistry.chemical_classification urogenital system Brain General Medicine Rats Cell biology Ki-67 Antigen medicine.anatomical_structure Liver chemistry Cattle Kidney Diseases Tumor Suppressor Protein p53 Oligopeptides Spleen Explant culture |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 159:124-127 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Polypeptide complex isolated from calf kidneys stimulates the processes of cell renewal in organotypic kidney tissue cultures from young and old rats. The polypeptide complex enhances expression of proliferation marker Ki-67 and reduces expression of proapoptotic peptide p53 in kidney explants obtained from young and old animals. Short peptides T-31 (AED) and T-35 (EDL) also stimulate proliferation and reduce apoptosis of the kidney cells, but to a lesser degree than the polypeptide complex. The results provide the basis for further investigation of the polypeptide complex as a preparation for the therapy of kidney diseases, including age-related pathologies. |
| Databáze: | OpenAIRE |
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