Vi antigen from Salmonella typhosa and immunity against typhoid fever. 11. Safety and antigenicity in humans
| Autor: | Robert S. Northrup, Kwei Hay Wong, Ann Sutton, Douglas M. Levin, Herbert Y. Reynolds |
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| Rok vydání: | 1975 |
| Předmět: |
Blood Bactericidal Activity
Antigenicity Immunology Salmonella typhi Microbiology Typhoid fever Epitopes Antigen Immunity medicine Humans Typhoid Fever Antigens Bacterial biology business.industry Typhoid-Paratyphoid Vaccines Hemagglutination Tests medicine.disease Virology Infectious Diseases Antibody Formation Typhoid vaccine biology.protein Parasitology Antibody business Research Article |
| Zdroj: | Infection and Immunity. 12:1290-1294 |
| ISSN: | 1098-5522 0019-9567 |
| Popis: | Safety and antigenicity of a purified preparation of Salmonella typhosa Vi antigen was evaluated in human volunteers. Dosages of Vi antigen at 25, 50, and 100 mug were less toxic than U.S. standard typhoid vaccine (lot 6A) containing 5 X 10(8) bacteria per dosage. Vi antigen in comparison with the standard typhoid vaccine induced higher hemagglutinating antibody but lower bactericidal antibody responses. |
| Databáze: | OpenAIRE |
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