Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages
| Autor: | McGovern, Naomi, Schlitzer, Andreas, Gunawan, Merry, Jardine, Laura, Shin, Amanda, Poyner, Elizabeth, Green, Kile, Dickinson, Rachel, Wang, Xiao-Nong, Low, Donovan, Best, Katie, Covins, Samuel, Milne, Paul, Pagan, Sarah, Aljefri, Khadija, Windebank, Martin, Miranda-Saavedra, Diego, Larbi, Anis, Wasan, Pavandip Singh, Duan, Kaibo, Poidinger, Michael, Bigley, Venetia, Ginhoux, Florent, Collin, Matthew, Haniffa, Muzlifah |
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| Přispěvatelé: | McGovern, Naomi [0000-0001-5200-2698], Apollo - University of Cambridge Repository |
| Rok vydání: | 2014 |
| Předmět: |
CD11b Antigen
Macrophages T-Lymphocytes Receptors IgG Immunology Lipopolysaccharide Receptors hemic and immune systems chemical and pharmacologic phenomena Cell Differentiation Mice Transgenic Dendritic Cells Article Mice Infectious Diseases Cell Movement Animals Humans Immunology and Allergy Cell Lineage Female Immunologic Memory Cells Cultured Skin |
| Zdroj: | Immunity |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/j.immuni.2014.08.006 |
| Popis: | Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi)XCR1⁺ CLEC9A⁺ DCs and CD1c⁺ DCs are murine CD103⁺ DCs and CD64⁻ CD11b⁺ DCs. In addition, human tissues also contain CD14⁺ cells, currently designated as DCs, with an as-yet unknown murine counterpart. Here we have demonstrated that human dermal CD14⁺ cells are a tissue-resident population of monocyte-derived macrophages with a short half-life of |
| Databáze: | OpenAIRE |
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