Endothelial nitric oxide synthase gene polymorphisms and the risk of acute myocardial infarction in a South Indian population
| Autor: | Ramamoorthy Padmapriya, Chandrasekaran Adithan, Jayaraman Balachandar, Annan Sudarsan Arun Kumar, Gurusamy Umamaheswaran |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Vascular smooth muscle Nitric Oxide Synthase Type III Myocardial Infarction India Vasodilation Polymorphism Single Nucleotide Linkage Disequilibrium Nitric oxide chemistry.chemical_compound Gene Frequency Polymorphism (computer science) Internal medicine Genotype Genetics Humans Medicine Genetic Predisposition to Disease Myocardial infarction Molecular Biology Genotyping Genetic Association Studies Aged Genes Dominant Models Genetic business.industry Sequence Analysis DNA General Medicine Odds ratio Middle Aged medicine.disease Endocrinology chemistry Case-Control Studies Female business Polymorphism Restriction Fragment Length |
| Zdroj: | Molecular Biology Reports. 40:1275-1281 |
| ISSN: | 1573-4978 0301-4851 |
| DOI: | 10.1007/s11033-012-2170-2 |
| Popis: | Myocardial infarction (MI) is a complex multi-factorial, polygenic disorder which results from an interaction between a person’s genetic makeup and various environmental factors. Nitric oxide (NO), a potent vasodilator produced by endothelial cells, plays an important role in the regulation of blood pressure, regional blood flow and also inhibits platelet aggregation, vascular smooth muscle cell proliferation and leukocyte adhesion to vascular endothelium. Our aim was to analyze the association of NOS3 (endothelial nitric oxide synthase 3) 894G>T and −786T>C gene polymorphisms and MI risk in the South Indian population. A total of 287 MI patients, 279 risk control patients and 321 healthy controls were recruited for the retrospective study. Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). There was no significant association observed between NOS3 894G>T, −786T>C polymorphisms and MI. A significant difference was observed in the distribution of GT genotype of the NOS3 894G>T polymorphism between the cases and the risk controls (p = 0.05) but the odds ratio (0.6) did not show risk for MI. The present study showed lack of association between NOS3 gene polymorphisms and MI in South Indian population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink