Short-Term Exposure to High Sucrose Levels near Weaning Has a Similar Long-Lasting Effect on Hypertension as a Long-Term Exposure in Rats

Autor: Verónica Guarner-Lans, Leonardo Del Valle-Mondragón, Mariana Villegas-Romero, Israel Pérez-Torres, Elizabeth Carreón-Torres, María Esther Rubio-Ruiz, Eulises Díaz-Díaz, Vicente Castrejón-Téllez
Rok vydání: 2018
Předmět:
0301 basic medicine
Blood Glucose
Male
Time Factors
Blood Pressure
medicine.disease_cause
chemistry.chemical_compound
Superoxide Dismutase-1
Enos
Dietary Sucrose
critical window
Ingestion
Insulin
oxidative stress
Adiposity
chemistry.chemical_classification
Metabolic Syndrome
Nutrition and Dietetics
biology
Endothelin-1
Age Factors
sucrose
Lipids
Arachidonic acid
lcsh:Nutrition. Foods and food supply
medicine.medical_specialty
hypertension
Nitric Oxide Synthase Type III
lcsh:TX341-641
Weaning
Nitric Oxide
fatty acids
Article
03 medical and health sciences
Internal medicine
medicine
Animals
Rats
Wistar
endothelial nitric oxide synthase
business.industry
Superoxide Dismutase
Fatty acid
biology.organism_classification
medicine.disease
Disease Models
Animal
030104 developmental biology
Endocrinology
Blood pressure
chemistry
Lipid Peroxidation
Metabolic syndrome
Insulin Resistance
business
Oxidative stress
Food Science
Zdroj: Nutrients
Nutrients, Vol 10, Iss 6, p 728 (2018)
Volume 10
Issue 6
ISSN: 2072-6643
Popis: Adverse conditions during early developmental stages permanently modify the metabolic function of organisms through epigenetic changes. Exposure to high sugar diets during gestation and/or lactation affects susceptibility to metabolic syndrome or hypertension in adulthood. The effect of a high sugar diet for shorter time lapses remains unclear. Here we studied the effect of short-term sucrose ingestion near weaning (postnatal days 12 and 28) (STS) and its effect after long-term ingestion, for a period of seven months (LTS) in rats. Rats receiving sucrose for seven months develop metabolic syndrome (MS). The mechanisms underlying hypertension in this model and those that underlie the effects of short-term exposure have not been studied. We explore NO and endothelin-1 concentration, endothelial nitric oxide synthase (eNOS) expression, fatty acid participation and the involvement of oxidative stress (OS) after LTS and STS. Blood pressure increased to similar levels in adult rats that received sucrose during short- and long-term glucose exposure. The endothelin-1 concentration increased only in LTS rats. eNOS and SOD2 expression determined by Western blot and total antioxidant capacity were diminished in both groups. Saturated fatty acids and arachidonic acid were only decreased in LTS rats. In conclusion, a high-sugar diet during STS increases the hypertension predisposition in adulthood to as high a level as LTS, and the mechanisms involved have similarities (participation of OS and eNOS and SOD expression) and differences (fatty acids and arachidonic acid only participate in LTS and an elevated level of endothelin-1 was only found in LTS) in both conditions. Changes in the diet during short exposure times in early developmental stages have long-lasting effects in determining hypertension susceptibility.
Databáze: OpenAIRE
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