| Autor: |
Michael D. Jones, Jonathan Bistline, Joshua M. Korn, Yiling Lu, Javad Golji, Michael Morrissey, Dale Porter, Robert Schlegel, Andrew A. Lane, Antoine de Weck, Manway Liu, James M. McFarland, Amanda L. Creech, Giordano Caponigro, Haoxin Li, Michael V. Rothberg, Christopher Lo, Franklin W. Huang, Juliann Shih, Ali Amin Mansour, Brian J. Haas, Judit Jané-Valbuena, Joseph Lehar, Nicolas Stransky, Rehan Akbani, Alexander Y. Andreev-Drakhlin, Gordon B. Mills, Kevin Hu, Gad Getz, Jaegil Kim, E. Robert McDonald, Mahdi Zamanighomi, Andrew D. Cherniack, Kevin Hadi, Francisca Vazquez, Frank Stegmeier, Mahmoud Ghandi, William C. Hahn, Ellen Gelfand, Michael S. Lawrence, Levi A. Garraway, Barbara A. Weir, Anupama Reddy, Todd R. Golub, Prafulla C. Gokhale, Audrey Kauffmann, Marcin Imielinski, François Aguet, Brenton R. Paolella, Allison Warren, Jacob D. Jaffe, Cory M. Johannessen, Jordi Barretina, Coyin Oh, Caitlin M. Dunning, William R. Sellers, Julian M. Hess, Dmitriy Sonkin, Hong L. Tiv, David M. Weinstock, Jesse S. Boehm, Aviad Tsherniak, Kavitha Venkatesan, Yanay Rosen, Jordan E. Taylor, Yosef E. Maruvka, Craig M. Bielski, Gregory V. Kryukov |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Nature, vol 569, iss 7757 |
| Popis: |
Large panels of comprehensively characterized human cancer models, including the Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study genetic variants, candidate targets, and small-molecule and biological therapeutics and to identify new marker-driven cancer dependencies. To improve our understanding of the molecular features that contribute to cancer phenotypes, including drug responses, here we have expanded the characterizations of cancer cell lines to include genetic, RNA splicing, DNA methylation, histone H3 modification, microRNA expression and reverse-phase protein array data for 1,072 cell lines from individuals of various lineages and ethnicities. Integration of these data with functional characterizations such as drug-sensitivity, short hairpin RNA knockdown and CRISPR-Cas9 knockout data reveals potential targets for cancer drugs and associated biomarkers. Together, this dataset and an accompanying public data portal provide a resource for the acceleration of cancer research using model cancer cell lines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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