Prognostic significance of PAK family kinases in acute myeloid leukemia

Autor: Lin Fu, Liang Quan, Jinlong Shi, Yang Jiao, Zhiheng Cheng, Yifeng Dai
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Oncology
Male
Cancer Research
IMPACT
medicine.medical_treatment
Regulator
Disease
Hematopoietic stem cell transplantation
Kaplan-Meier Estimate
0302 clinical medicine
AML
Bone Marrow
Risk Factors
Antineoplastic Combined Chemotherapy Protocols
ADULT PATIENTS
Aged
80 and over
Kinase
Gene Expression Regulation
Leukemic
Hematopoietic Stem Cell Transplantation
Myeloid leukemia
Middle Aged
Prognosis
Leukemia
Myeloid
Acute
P21-ACTIVATED KINASE-5
PREDICTS ADVERSE PROGNOSIS
030220 oncology & carcinogenesis
Molecular Medicine
Female
Adult
HIGH EXPRESSION
medicine.medical_specialty
Disease-Free Survival
03 medical and health sciences
Young Adult
Internal medicine
Cancer genome
medicine
Biomarkers
Tumor
Humans
Transplantation
Homologous
In patient
Molecular Biology
Aged
Chemotherapy
business.industry
MUTATIONS
Protective Factors
030104 developmental biology
p21-Activated Kinases
business
Zdroj: Cancer Gene Therapy, 27(1-2), 30-37. Nature Publishing Group
ISSN: 0929-1903
Popis: Acute myeloid leukemia (AML) is a clonal and heterogeneous disease characterized by a myriad of genetic defects. Genetic abnormalities are powerful prognostic factors. P21-activated kinases (PAKs) are a kind of serine/threonine protein kinases, which is regulator of plenty of oncogenic signaling pathways. The clinical and prognostic value of PAKs in AML is unclear. A total of 155 AML patients with PAK expression data from The Cancer Genome Atlas database were enrolled in this study. Eighty-four patients underwent chemotherapy only, 71 also underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the chemotherapy-only group, high PAK3 and PAK7 expression were both bound up with poor EFS and OS (all P
Databáze: OpenAIRE
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