Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome
| Autor: | Tamer Sari, Ziya Kalem, Can Ateş, Timur Gurgan, Müberra Namlı Kalem |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment lcsh:Medicine Physiology body mass index lcsh:Gynecology and obstetrics 03 medical and health sciences 0302 clinical medicine Internal medicine medicine 030212 general & internal medicine lcsh:RG1-991 Ivf outcome Original Investigation 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry pcos lcsh:R Obstetrics and Gynecology Polycystic ovary female genital diseases and pregnancy complications ivf outcome Endocrinology age business Body mass index |
| Zdroj: | Journal of the Turkish-German Gynecological Association, Vol 17, Iss 2, Pp 83-90 (2016) |
| ISSN: | 1309-0380 1309-0399 |
| DOI: | 10.5152/jtgga.2016.15235 |
| Popis: | Objective: The aim of this study was to investigate age-related variations in the effect of body mass index (BMI) on in vitro fertilization (IVF) outcomes.Material and Methods: This was a cohort study conducted by retrospectively investigating the IVF cycles of 653 polycystic ovary syndrome (PCOS) patients under the age of 40 years who were diagnosed based on the Rotterdam criteria in a private IVF clinic between 2005 and 2015. The study included data from 653 IVF cycles of PCOS patients. The patients were classified into three groups based on their BMI, i.e., normal weight (n=299), overweight (n=208), and obese (n=146). The patients were also grouped by age: 562 patients were under the age of 35 years and 91 patients were above the age of 35 years. Then, BMI- and age-related variations in the IVF cycle parameters and clinical pregnancy rates of patients with PCOS were investigated. The Mantel–Haenszel Chi-square statistical assessment method was used to determine whether the effect of BMI on IVF outcomes varies with age.Results: Variations in cycle variables with BMI and age showed that IVF cycles were negatively affected by increases in obesity and age. Clinical pregnancy rates were found to be lower in the obese group than in the other groups, particularly in the age group above 35 years; however, this difference could not be proven statistically.Conclusion: The present study evaluated obesity and clinical pregnancy rates in IVF cycles in PCOS patients according to age groups, and particularly in the obese group, the clinical pregnancy rates were observed to be lower in the age group ≥35 years than in the other BMI groups; however, this difference was found to be statistically insignificant. |
| Databáze: | OpenAIRE |
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