Regulation of male sex determination: genital ridge formation and Sry activation in mice
| Autor: | Ryuichi Nishinakamura, Satomi S. Tanaka |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Nr5a1/Ad4BP/Sf1
Male medicine.medical_specialty Six1 endocrine system Six4 Male sex determination Review Biology Genitalia Male Y chromosome Andrology Mice Cellular and Molecular Neuroscience Internal medicine medicine Animals Humans Sex organ Disorders of sex development Molecular Biology Pharmacology Sexual differentiation Gonadal ridge Models Genetic Transcriptional network Gene Expression Regulation Developmental SOX9 Transcription Factor Cell Biology Sex Determination Processes medicine.disease Sex-Determining Region Y Protein Endocrinology Testis determining factor Primary sex determination Molecular Medicine Sox9 |
| Zdroj: | Cellular and Molecular Life Sciences |
| ISSN: | 1420-682X |
| DOI: | 10.1007/s00018-014-1703-3 |
| Popis: | Sex determination is essential for the sexual reproduction to generate the next generation by the formation of functional male or female gametes. In mammals, primary sex determination is commenced by the presence or absence of the Y chromosome, which controls the fate of the gonadal primordium. The somatic precursor of gonads, the genital ridge is formed at the mid-gestation stage and gives rise to one of two organs, a testis or an ovary. The fate of the genital ridge, which is governed by the differentiation of somatic cells into Sertoli cells in the testes or granulosa cells in the ovaries, further determines the sex of an individual and their germ cells. Mutation studies in human patients with disorders of sex development and mouse models have revealed factors that are involved in mammalian sex determination. In most of mammals, a single genetic trigger, the Y-linked gene Sry (sex determination region on Y chromosome), regulates testicular differentiation. Despite identification of Sry in 1990, precise mechanisms underlying the sex determination of bipotential genital ridges are still largely unknown. Here, we review the recent progress that has provided new insights into the mechanisms underlying genital ridge formation as well as the regulation of Sry expression and its functions in male sex determination of mice. |
| Databáze: | OpenAIRE |
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