Serum levels of selected micronutrients in patients with inflammatory bowel disease in clinical remission
| Autor: | Agnieszka Dąbek-Drobny, Magdalena Przybylska-Feluś, Małgorzata Zwolińska-Wcisło, Agnieszka Piątek-Guziewicz, Paweł Zagrodzki, Paweł Paśko, Tomasz Mach, Olga Kaczmarczyk, Kacper Wcisło |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty medicine.diagnostic_test Anemia business.industry Complete blood count Inflammatory Bowel Diseases medicine.disease Positive correlation Micronutrient Gastroenterology Serum selenium Inflammatory bowel disease Trace Elements Zinc Internal medicine Internal Medicine medicine Humans In patient Micronutrients Hemoglobin business Copper |
| Popis: | Introduction Micronutrient deficiency can occur in patients with inflammatory bowel disease (IBD) regardless of the disease activity and extent. Objectives We aimed to evaluate the serum concentrations of selected trace elements in adult patients with IBD in clinical remission, with involvement limited to the colon, and receiving immunosuppressive treatment. Patients and methods We enrolled 32 patients with IBD (mean [SD] age, 41.0 [15.2] years) and 30 healthy controls (mean [SD] age, 39.1 [11.8] years). Serum selenium (Se), iron (Fe), copper (Cu), and zinc (Zn) levels as well as complete blood count were measured in both groups. Results Patients with IBD had lower Zn concentrations than controls (mean [SD], 0.76 [0.13] mg/l vs 0.83 [0.13] mg/l, P = 0.047). No significant differences were observed for Se (mean [SD], 0.90 [0.24] μmol/l vs 0.93 [0.19] μmol/l) and Cu levels (mean [SD], 1.03 [0.27] mg/l vs 0.97 [0.22] mg/l). Compared with controls, patients with IBD had lower red blood cell count (mean [SD], 4.4 [0.6] 106/ml vs 4.7 [0.4] 106/ml, P = 0.03), hemoglobin (mean [SD], 12.7 [2.2] g/dl vs 14.3 [0.8] g/dl, P = 0.001), and Fe levels (mean [SD], 14.2 [9.4] μmol/l vs 23.4 [2.7] μmol/l, P=0.0001). Patients with IBD showed a positive correlation between Se and Fe (R = 0.499; P = 0.004) as well as Se and hemoglobin levels (R = 0.579; P = 0.001). Conclusions Patients with IBD, despite maintaining clinical remission, should undergo systematic laboratory test for anemia or micronutrient deficiencies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|