Cerebellar Hemangioblastoma: Diagnostic Yield of Contrast-Enhanced Abdominal CT and Whole-Spine MRI as Initial Screening Imaging
| Autor: | Sang Joon Kim, Jeong Hoon Kim, Ho Sung Kim, Chong Hyun Suh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty von Hippel-Lindau Disease Abdominal ct Contrast Media Newly diagnosed 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Hemangioblastoma Abdomen medicine Humans Mass Screening Radiology Nuclear Medicine and imaging In patient Von Hippel–Lindau disease Cerebellar Neoplasms Retrospective Studies Spinal Neoplasms business.industry Retrospective cohort study Mean age General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging 030220 oncology & carcinogenesis Female Cerebellar hemangioblastoma Radiology Tomography X-Ray Computed business |
| Zdroj: | American Journal of Roentgenology. 215:706-712 |
| ISSN: | 1546-3141 0361-803X |
| Popis: | OBJECTIVE. The existing literature lacks research into the benefits of initial screening imaging for patients with cerebellar hemangioblastoma. We aimed to evaluate the diagnostic yield of initial screening imaging using abdominal CT and whole-spine MRI in patients with cerebellar hemangioblastoma. MATERIALS AND METHODS. This retrospective study included 117 consecutive patients with histopathologically confirmed, newly diagnosed cerebellar hemangioblastomas at a single tertiary hospital between January 2006 and October 2018. Patients underwent contrast-enhanced abdominal CT, whole-spine MRI, or both to detect abdominal and spinal lesions of von Hippel-Lindau disease. Diagnostic yields and false referral rates for initial screening imaging were determined. RESULTS. After exclusion of six patients who forewent any initial imaging, 111 patients were included (53 men [mean age ± SD, 51 ± 13 years] and 58 women [mean age, 43 ± 16 years]). The diagnostic yield of abdominal CT was 3.8% (4 of 105; 95% CI, 1.1-9.3%), whereas the false referral rate was 1.0% (1 of 105; 95% CI, 0.0-5.2%). For whole-spine MRI, the corresponding values were 5.6% (4 of 71; 95% CI, 1.6-13.8%) and 2.8% (2 of 71; 95% CI, 0.3-9.8%), respectively. The respective diagnostic yields in patients with a single cerebellar hemangioblastoma were both 0% (0 of 98 and 66, respectively). CONCLUSION. For patients with a single cerebellar hemangioblastoma, screening examinations with abdominal CT and whole-spine MRI are unnecessary before the results of genetic testing are available. |
| Databáze: | OpenAIRE |
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