Better postprandial glucose stability during continuous subcutaneous infusion with insulin aspart compared with insulin lispro in patients with type 1 diabetes
| Autor: | Valerio Miselli, Piero Meandri, Emanuele Bosi, Tiziano Fabbri, Francesco Cannatà, Antonio Scaramuzza, Sara Brandolini, Paolo Di Bartolo, Francesca Pellicano, Tino Casetti, Cipriana Sardu |
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| Rok vydání: | 2008 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Time Factors endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Infusions Subcutaneous Insulin aspart Eating Endocrinology Insulin Infusion Systems Diabetes mellitus Internal medicine medicine Insulin lispro Humans Insulin Insulin Aspart Glycemic Type 1 diabetes Cross-Over Studies Insulin Lispro business.industry digestive oral and skin physiology nutritional and metabolic diseases medicine.disease Postprandial Period Crossover study Medical Laboratory Technology Postprandial Diabetes Mellitus Type 1 Area Under Curve business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Diabetes technologytherapeutics. 10(6) |
| ISSN: | 1520-9156 |
| Popis: | Persistent glucose variability is a frequent condition in type 1 diabetes. Continuous subcutaneous insulin infusion (CSII) is a rational option to overcome this clinical issue; however, no comparative studies have been reported for aspart and lispro insulin when used in CSII. This study compare the effects of aspart and lispro delivered by CSII on glycemic stability as measured using a continuous glucose monitoring system.This single-center, randomized, controlled, 3-day crossover trial included 17 patients with type 1 diabetes. Patients were randomized to receive insulin aspart or insulin lispro. The next day, they received a standard meal at breakfast and lunch and a bolus of insulin aspart or lispro based on insulin:carbohydrate ratio. Patients were monitored for 8 h, after which they received a crossover treatment with insulin aspart or insulin lispro followed by the same procedure as previously.Postprandial blood glucose was more stable with insulin aspart than insulin lispro (absolute Deltaglucose 7.04 +/- 3.16 vs. 9.04 +/- 4.2, P0.0019). Daily blood glucose variability profiles (coefficient of variation and mean amplitude of glucose excursion) and frequency of hypoglycemic episodes (area under the curve72 mg/dL) were similar with both treatments.Postprandial glucose was more stable when insulin aspart was infused as a pre-meal bolus compared with insulin lispro, indicating a more favorable effect of insulin aspart on postprandial glucose. No differences in overall daily glucose stability were observed between insulin aspart and insulin lispro when infused as basal rate insulin. |
| Databáze: | OpenAIRE |
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