Is Invasive Micropapillary Serous Carcinoma a Low-grade Carcinoma?
| Autor: | Tsunehisa Kaku, Kaai Shida, Kiyoko Kato, Yoshinao Oda, Murasaki Aman, Yoshihiro Ohishi, Hiroko Imamura |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Proto-Oncogene Proteins B-raf 0301 basic medicine Pathology medicine.medical_specialty endocrine system diseases Serous carcinoma DNA Mutational Analysis Pathology and Forensic Medicine Proto-Oncogene Proteins p21(ras) Young Adult 03 medical and health sciences 0302 clinical medicine medicine Carcinoma Humans Neoplasm Invasiveness Nuclear atypia Peritoneal Neoplasms Aged Ovarian Neoplasms business.industry Obstetrics and Gynecology Middle Aged medicine.disease Immunohistochemistry Carcinoma Papillary female genital diseases and pregnancy complications Cystadenocarcinoma Serous Micropapillary Serous Carcinoma Micropapillary pattern Serous fluid 030104 developmental biology 030220 oncology & carcinogenesis Mutation Female Neoplasm Grading Tumor Suppressor Protein p53 business |
| Zdroj: | International Journal of Gynecological Pathology. 35:56-65 |
| ISSN: | 0277-1691 |
| DOI: | 10.1097/pgp.0000000000000211 |
| Popis: | "Invasive micropapillary serous carcinoma" has been proposed as a synonym for low-grade serous carcinoma by some expert pathologists. In contrast, Singer and colleagues reported that some serous carcinomas with conspicuous invasive micropapillary pattern (SC-IMPs) can show high-grade nuclear atypia. However, the molecular features of such tumors have not been well documented. The aim of this study was to demonstrate and emphasize the fact that high-grade serous carcinoma confirmed by immunohistochemistry and molecular analysis can show conspicuous invasive micropapillary pattern. We selected 24 "SC-IMPs" and investigated: (1) their morphologic features; (2) the immunostaining pattern of p53 protein; and (3) KRAS/BRAF/TP53 gene mutations. The 24 SC-IMPs were subdivided into low-grade and high-grade tumors based primarily on the nuclear atypia, with the mitotic rate used as a secondary feature: low grade (n=5) and high grade (n=19). Low-grade SC-IMPs were characterized by low-mitotic activity, absence of abnormal mitosis, presence of serous borderline tumor, occasional BRAF mutation, and infrequent TP53 mutation. High-grade SC-IMPs were characterized by high-mitotic activity, presence of abnormal mitosis, conventional high-grade serous carcinoma, frequent TP53 mutation, and lack of KRAS/BRAF mutation. We demonstrated that high-grade serous carcinoma confirmed by aberrant p53 immunostaining and molecular analysis can show conspicuous invasive micropapillary pattern, validating Singer and colleague's report. Serous carcinoma with conspicuous invasive micropapillary pattern should not be readily regarded as low-grade serous carcinoma. Nuclear grade is the most important diagnostic feature in the SC-IMPs. |
| Databáze: | OpenAIRE |
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