Correlations of Calf Muscle Macrophage Content With Muscle Properties and Walking Performance in Peripheral Artery Disease
| Autor: | Michael H. Criqui, Charlotte A. Peterson, Mary M. McDermott, Kate Kosmac, R. Grace Walton, S H White, Robert L. Sufit, Luigi Ferrucci, Christiaan Leeuwenburgh, Jack M. Guralnik, Tamar S. Polonsky, Melina R. Kibbe, Marta Gonzalez-Freire, Lu Tian, Lingyu Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Aging Physiology Cell humanos Walking 030204 cardiovascular system & hematology Cardiorespiratory Medicine and Haematology Cardiovascular Extracellular matrix 0302 clinical medicine Immunologic walking performance Receptors macrófagos Macrophage Arrhythmia and Electrophysiology Receptors Immunologic mediana edad Original Research Randomized Controlled Trials as Topic 0303 health sciences anciano CD11b Antigen Membrane Glycoproteins glicoproteínas de membranas biology Stem Cells ensayos clínicos controlados aleatorizados como asunto Skeletal Middle Aged Adaptation Physiological Extracellular Matrix Satellite Cells Observational Studies as Topic medicine.anatomical_structure Phenotype Integrin alpha M Immunohistochemistry Muscle fenotipo Female Cardiology and Cardiovascular Medicine Microvascular Density medicine.medical_specialty Skeletal Muscle Satellite Cells Skeletal Muscle Physiological estudios de casos y controles Skeletal muscle adaptation macrophage arteriopatía periférica peripheral artery disease matriz extracelular 03 medical and health sciences Peripheral Arterial Disease Internal medicine medicine Humans Adaptation skeletal muscle Muscle Skeletal caminata 030304 developmental biology Aged Inflammation Cluster of differentiation business.industry Macrophages Skeletal muscle Endocrinology Cross-Sectional Studies Peripheral Vascular Disease Musculoskeletal Case-Control Studies biology.protein business Biomarkers estudios transversales |
| Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease Journal of the American Heart Association, vol 9, iss 10 |
| Popis: | BACKGROUND: Peripheral artery disease (PAD) is a manifestation of atherosclerosis characterized by reduced blood flow to the lower extremities and mobility loss. Preliminary evidence suggests PAD damages skeletal muscle, resulting in muscle impairments that contribute to functional decline. We sought to determine whether PAD is associated with an altered macrophage profile in gastrocnemius muscles and whether muscle macrophage populations are associated with impaired muscle phenotype and walking performance in patients with PAD. METHODS AND RESULTS: Macrophages, satellite cells, and extracellular matrix in gastrocnemius muscles from 25 patients with PAD and 7 patients without PAD were quantified using immunohistochemistry. Among patients with PAD, both the absolute number and percentage of cluster of differentiation (CD) 11b+CD206+ M2-like macrophages positively correlated to satellite cell number (r=0.461 [P=0.023] and r=0.416 [P=0.042], respectively) but not capillary density or extracellular matrix. The number of CD11b+CD206- macrophages negatively correlated to 4-meter walk tests at normal (r=-0.447, P=0.036) and fast pace (r=-0.510, P=0.014). Extracellular matrix occupied more muscle area in PAD compared with non-PAD (8.72 +/- 2.19% versus 5.30 +/- 1.03%, P The work was supported by National Institutes of Health grants R01HL0 88589, R01HL083064, R01HL089619, R01HL107510, R21AG047510, R01 HL109244, and R01HL126117 (McDermott). |
| Databáze: | OpenAIRE |
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