Hepatitis B and C virus markers among patients with hepatosplenic mansonic schistosomiasis
| Autor: | Renata Aquino, Ernani Geraldo Rolim, Manoel Carlos Sampaio de Almeida Ribeiro, Maria Fátima Araújo, Eliane Figueiredo Taddeo, Pedro Paulo Chieffi, Sônia de Marques Catunda |
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| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male HBsAg lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Schistosomiasis C Virus Statistics Nonparametric Virus Serology Hepatitis Risk Factors medicine Humans Decompensation Hepatitis B Antibodies Aged Splenic Diseases Chi-Square Distribution B Virus business.industry General Medicine Hepatitis C Hepatitis C Antibodies Middle Aged Hepatitis B medicine.disease Schistosomiasis mansoni Infectious Diseases Mansonic Schistosomiasis Case-Control Studies Immunology Female business Biomarkers |
| Zdroj: | Revista do Instituto de Medicina Tropical de São Paulo, Vol 42, Iss 6, Pp 313-320 (2000) |
| ISSN: | 1678-9946 0036-4665 |
| Popis: | PURPOSE: To evaluate the frequency and the consequences of the co-infection of hepatitis B and C viruses in patients with hepatosplenic schistosomiasis (HSS). METHODS: B and C serologic markers, exposure to risk factors, biochemical assays, upper gastrointestinal endoscopies, and abdominal ultrasonograms were evaluated in 101 patients with HSS from 1994 to 1997. Whenever possible, PCR was tested and histopathological studies were reviewed. RESULTS: At least one HBV virus marker was found in 15.8%, and anti-HCV was detected in 12.9% of the subjects. The seropositive subjects tended to be older than the seronegative ones. A history of blood transfusion was significantly related to the presence of anti-HCV. Three (18.75%) out of 16 subjects exposed to B virus were HBsAg positive. Eleven (84.6%) out of thirteen patients who were anti-HCV positive demonstrated viral activity. Patients with ongoing viral infection presented a higher average level of liver aminotransferases, a higher frequency of cell decompensation and a higher rate of chronic hepatitis. Portal hypertension parameters were not influenced by viral exposure. CONCLUSIONS: The rate of hepatitis B and C viruses serologic markers observed in the patients with HSS was higher than the control group. The co-infection was responsible for a higher frequency of cell decompensation. |
| Databáze: | OpenAIRE |
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