Synthesis andIn vitro cytotoxicity of 4-alkyl- or 4-arylaminosub-stituted cyclopenta[c]quinoline derivatives
| Autor: | Sung-ll Yang, Jeeman Lee, Heesoon Lee |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Magnetic Resonance Spectroscopy
Chemical Phenomena Cell Survival Stereochemistry Antineoplastic Agents Pyrrolidine chemistry.chemical_compound Drug Discovery Tumor Cells Cultured Side chain medicine Humans Doxorubicin Cytotoxicity Alkyl chemistry.chemical_classification Chemistry Physical Organic Chemistry Quinoline DNA In vitro chemistry Cell culture Aminoquinolines Molecular Medicine Indicators and Reagents Heterocyclic Compounds 3-Ring medicine.drug |
| Zdroj: | Archives of Pharmacal Research. 24:385-389 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/bf02975180 |
| Popis: | Twelve 4-substituted cyclopenta[c]quinoline derivatives were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T-47D). The compounds 6c and 6e bearing p-anisidine and pyrrolidine side chain were more active than the others. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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