Chemokine interaction with synergy-inducing molecules: fine tuning modulation of cell trafficking
Autor: | Gianluca D'Agostino, Lorenzo Raeli, Mariagrazia Uguccioni, Valentina Cecchinato |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
CCR1 cell migration Immunology Reviews Biology CCL7 Models Biological 03 medical and health sciences Chemokine receptor chemokine activities Cell Movement Animals Humans Immunology and Allergy CCR10 CXC chemokine receptors HMGB1 Protein CCL13 HMGB1 Cell Biology CXCL12 3. Good health Cell biology 030104 developmental biology Multiprotein Complexes CXCL9 Chemokines CCL21 |
Zdroj: | JOURNAL OF LEUKOCYTE BIOLOGY J Leukoc Biol Journal of Leukocyte Biology |
DOI: | 10.1189/jlb.1MR1015-457R |
Popis: | Review on synergistic activities induced by heterocomplexes formed with chemokines. Directed migration and arrest of leukocytes during homeostasis, inflammation, and tumor development is mediated by the chemokine system, which governs leukocyte migration and activities. Although we understand well the effects of different chemokines one by one, much less was known about the potential consequences of the concomitant expression of multiple chemokines or of their interaction with inflammatory molecules on leukocyte migration and functions. In the past 10 yr, several studies revealed the existence of additional features of chemokines: they can antagonize chemokine receptors or synergize with other chemokines, also by forming heterocomplexes. Moreover, recent data show that not only chemokines but also the alarmin high-mobility group box 1 can for a complex with CXCL12, enhancing its potency on CXCR4. The molecular mechanism underlying the effect of the heterocomplex has been partially elucidated, whereas its structure is a matter of current investigations. The present review discusses the current knowledge and relevance of the functions of heterocomplexes formed between chemokines or between the chemokine CXCL12 and the alarmin high-mobility group box 1. These studies highlight the importance of taking into account, when approaching innovative therapies targeting the chemokine system, also the fact that some chemokines and molecules released in inflammation, can considerably affect the activity of chemokine receptor agonists. |
Databáze: | OpenAIRE |
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