Development of a Murine Model of Chronic Rhinosinusitis
| Autor: | Monica Tadros, Natalie Ann-Marie Earl, Tiffani Slaughter, William E. Bolger, David Fox, Steven R. Mog, John Roberts, Rich Conran, Joy Britton-Webb, Robin W. Lindsay |
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| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty Antigens Fungal 040301 veterinary sciences medicine.medical_treatment Intraperitoneal injection Mucous membrane of nose Inflammation 0403 veterinary science Mice 03 medical and health sciences 0302 clinical medicine Antigen Eosinophilia Eosinophilic Animals Medicine Sinusitis 030223 otorhinolaryngology Administration Intranasal Rhinitis Mice Inbred BALB C business.industry Aspergillus fumigatus 04 agricultural and veterinary sciences Hyperplasia medicine.disease Disease Models Animal Otorhinolaryngology Murine model Chronic Disease Immunology Disease Progression Female Surgery Nasal administration medicine.symptom business Follow-Up Studies |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 134:724-730 |
| ISSN: | 1097-6817 0194-5998 |
| Popis: | The aim of this study was to develop a mouse model of chronic eosinophilic rhinosinusitis.Mice were sensitized to Aspergillis fumigatus (Af) extract by intraperitoneal injection. The animals subsequently received nasal challenges with Af extract 3 times per week for 12 weeks. Sinonasal complexes were studied histologically by the study otolaryngologists and pathologists to characterize the inflammatory response.Animal care facility at an academic institution.A chronic eosinophilic inflammatory response was evoked in all study animals. Statistical analysis was performed for inflammation, secretory cell hyperplasia, mast cells, and eosinophils. There were very significant differences (P0.0005) between control and study mice in all categories.Prolonged nasal challenge of Af extract creates an inflammatory response in murine nasal mucosa that mimics human chronic eosinophilic rhinosinusitis.A murine model for chronic rhinosinusitis is reported that may facilitate future investigations into disease pathophysiology.B-2. |
| Databáze: | OpenAIRE |
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