Myostatin gene promoter: structure, conservation and importance as a target for muscle modulation
| Autor: | Lúcia Elvira Alvares, Carla Vermeulen Carvalho Grade, Carolina Stefano Mantovani |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
TATA box CAAT box SNP E-box Review Computational biology Myostatin Biochemistry 03 medical and health sciences Transcription factors Transcription factor lcsh:SF1-1100 Regulation of gene expression lcsh:Veterinary medicine biology Myogenesis 0402 animal and dairy science Promoter 04 agricultural and veterinary sciences 040201 dairy & animal science 030104 developmental biology Gene promoter biology.protein lcsh:SF600-1100 Animal Science and Zoology lcsh:Animal culture Food Science Biotechnology |
| Zdroj: | Journal of Animal Science and Biotechnology Journal of Animal Science and Biotechnology, Vol 10, Iss 1, Pp 1-19 (2019) |
| ISSN: | 2049-1891 |
| DOI: | 10.1186/s40104-019-0338-5 |
| Popis: | Myostatin (MSTN) is one of the key factors regulating myogenesis. Because of its role as a negative regulator of muscle mass deposition, much interest has been given to its protein and, in recent years, several studies have analysed MSTN gene regulation. This review discusses the MSTN gene promoter, focusing on its structure in several animal species, both vertebrate and invertebrate. We report the important binding sites considering their degree of phylogenetic conservation and roles they play in the promoter activity. Finally, we discuss recent studies focusing on MSTN gene regulation via promoter manipulation and the potential applications they have both in medicine and agriculture. Electronic supplementary material The online version of this article (10.1186/s40104-019-0338-5) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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