Erratum to 'Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study'
| Autor: | Bela B. Toth, Terence J. Fleming, Mark S. Chambers, Otis Bouwsma, Tibor Sipos, Harris J. Keene, Mark A. Espeland, Adam S. Garden, Jack W. Martin, Timothy E. Craven, James C. Lemon |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Cancer Research Administration Topical Population Dentistry Pilot Projects Dental Caries Xerostomia law.invention Streptococcus mutans chemistry.chemical_compound Randomized controlled trial law Streptococcal Infections Sodium fluoride Dentifrice Humans Medicine Single-Blind Method education Aged Proportional Hazards Models Aged 80 and over Mouth neoplasm education.field_of_study Radiotherapy business.industry Middle Aged Anti-Bacterial Agents Treatment Outcome Oncology Tolerability chemistry Delayed-Action Preparations Sodium Fluoride Population study Female Mouth Neoplasms Oral Surgery business Fluoride Tablets |
| Zdroj: | Oral Oncology. 43:98-105 |
| ISSN: | 1368-8375 |
| DOI: | 10.1016/j.oraloncology.2005.12.031 |
| Popis: | Radiation-induced xerostomia can result in the rapid onset and progression of dental caries in head and neck cancer patients. Topically applied fluorides have been successfully used to inhibit the formation of dental caries in this population. However, because intensive daily self-application is required, compliance is an issue. The intraoral fluoride-releasing system (IFRS) containing a sodium fluoride core is a newly developed, sustained-release, passive drug delivery system that does not require patient involvement except for periodic replacement, thus reducing the effect of patient compliance on its effectiveness in dental caries prevention. Twenty-two head and neck cancer patients from U. T. M. D. Anderson Cancer Center, with radiation-induced xerostomia, were entered into a pilot study to contrast the daily home use of a 0.4% stannous fluoride-gel-containing tray (control group) to IFRS (study group) with respect to tolerability and adherence, and to obtain information on relative caries preventive efficacy. Participants were stratified on the basis of radiation exposure and randomly assigned to treatment with either IFRS or stannous fluoride gel. Patients in both groups were fitted with two IFRS retainers and also were instructed to use a 1100-ppm fluoride conventional sodium fluoride dentifrice twice daily. The study was conducted as a single-blinded, parallel-cell trial. Pre-existing carious lesions were restored prior to the beginning of the study. The efficacy variable was determined by the mean number of new or recurrent decayed surfaces. Patients were examined for caries 4, 8, 12, 24, 36, and 48 weeks after initiation of treatment. Reports of adverse reactions were based on information volunteered by patients and that were elicited during interviews. At baseline, the resting and stimulated salivary flow rates (g/5min) were significantly greater in the control group than in the study group (p |
| Databáze: | OpenAIRE |
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