Cyclosporin A Reversed Chemoresistance of a Patient with Pure Red Cell Aplasia Secondary to Thymoma
| Autor: | Hongjin Chu, Jian Chen, Fengcai Du, Zhaohua Gong, Peng Li, Baohong Hu, Cheng Chi |
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| Rok vydání: | 2017 |
| Předmět: |
Drug
Male Cancer Research Thymoma media_common.quotation_subject medicine.medical_treatment Pure red cell aplasia Red-Cell Aplasia Pure 03 medical and health sciences 0302 clinical medicine Fatal Outcome hemic and lymphatic diseases Cyclosporin a Antineoplastic Combined Chemotherapy Protocols Medicine Humans media_common Chemotherapy business.industry General Medicine Aplasia Middle Aged medicine.disease Oncology Docetaxel Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer research Cyclosporine Efflux business Tomography X-Ray Computed Immunosuppressive Agents medicine.drug |
| Zdroj: | Anticancer research. 37(8) |
| ISSN: | 1791-7530 |
| Popis: | CASE REPORT This case study reports on a patient who relapsed with thymoma (mixed type) nine years after tumor resection. After four courses of rescue chemotherapy (docetaxel and cisplatinum), the patient was further diagnosed with pure red cell aplasia. It was noticed that cyclosporin A (CsA), which was administered to treat aplasia, could reverse chemoresistance. Its mechanism is not completely clear, but the hypothesis of CsA inhibiting P-glycoprotein mediated drug efflux is the most acceptable. |
| Databáze: | OpenAIRE |
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